ArticleScience (New York, N.Y.)2021
Cross-reactive CD4
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Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 1 of them a synthesis that pooled it.
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214citing papers in PubMed, 1 pooled it
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Who cites it
214 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systemic review of T-cell epitopes defined from the proteome of SARS-CoV-2.Virus research · 2023Pooled it
- Durability of ChAdOx1 nCoV-19 vaccination in people living with HIV.JCI insight · 2022Trial
- Trial
- CD4+ T cells from COVID-19 mRNA vaccine recipients recognize a conserved epitope present in diverse coronaviruses.The Journal of clinical investigation · 2022Trial
- Development of a unified mass cytometry assay integrating activation-induced markers (AIMs) and cytokine profiling for high-throughput assessment of antigen-specific T cell responses.Human vaccines & immunotherapeutics · 2026Article
- The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity.Immunological reviews · 2026Review
- Article
- Article
- Decoding the human CD4Cell reports. Medicine · 2026Article
- Comprehensive mapping of human CD4Cell reports. Medicine · 2026Article
- Discordant Outcomes of SARS-CoV-2 Exposure in Household Contacts.Clinical immunology communications · 2026Article
- Preexisting Humoral Immunity Against Seasonal Coronaviruses Enhances Antibody Responses on SARS-CoV-2 Vaccination.Open forum infectious diseases · 2026Article
- HKU1 immune imprinting is associated with post-COVID symptoms after SARS-CoV-2 infection.iScience · 2026Article
- Pre-COVID-19 ex vivo cross-reactive IFN-γ cellular response to SARS-CoV-2 spike overlapping peptides is more prevalent among Kenyan compared to Swedish adults.BMC infectious diseases · 2026Article
- Broad and robust T cell immunity compensates the population immune barrier against antibody-escaping Omicron variants.Frontiers in immunology · 2026Article
- Conformational bias in SARS-CoV-2 Spike CD4+ T-cell epitope dominance.Frontiers in immunology · 2026Article
- A Roadmap Towards the Identification and Validation of Conserved T Cell Epitope Regions in Viral Pathogen Families with Pandemic Potential.Current pharmaceutical biotechnology · 2026Article
- Systematic Determinants of Global COVID-19 Burden: Longitudinal Time-Series Analysis Using Big Data-Driven Artificial Intelligence.Journal of medical Internet research · 2025Article
- IL-10- and IL-13-Biased T Cell Responses to SARS-CoV-2 Vaccination in Diabetes.European journal of immunology · 2025Article
- The emerging role of the gut microbiota in vaccination responses.Gut microbes · 2025Review
154 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors.
Lucie LoyalSi-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-5738-4437
Julian Braun *Si-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-7788-8154
Larissa Henze *Si-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-6540-4263
Beate Kruse *Si-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Manuela Dingeldey *Si-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-8412-3910
Ulf Reimer *JPT Peptide Technologies GmbH, Berlin, Germany.ORCID 0000-0002-3375-6889
Florian Kern *JPT Peptide Technologies GmbH, Berlin, Germany.ORCID 0000-0002-0368-8408
Tatjana Schwarz *Institute of Virology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-6054-4750
Maike MangoldSi-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-4547-7246
Clara UngerSi-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-3760-4791
Friederike DörflerSi-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Shirin KadlerSi-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-9281-4770
Jennifer RosowskiSi-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Kübrah GürcanSi-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Zehra Uyar-AydinSi-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-6042-8311
Marco FrentschDepartment of Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Florian KurthDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-3807-473X
Karsten SchnatbaumJPT Peptide Technologies GmbH, Berlin, Germany.ORCID 0000-0002-2840-6294
Maren EckeyJPT Peptide Technologies GmbH, Berlin, Germany.ORCID 0000-0002-1431-1569
Stefan HippenstielDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-5146-1064
Andreas HockeDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-6935-8612
Marcel A MüllerCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0003-2242-5117
Birgit SawitzkiInstitute of Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-8166-8579
Stefan MiltenyiMiltenyi Biotec GmbH, Bergisch-Gladbach, Germany.
Friedemann PaulExperimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-6378-0070
Marcus A MallDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-4057-2199
Holger WenschuhJPT Peptide Technologies GmbH, Berlin, Germany.
Sebastian VoigtDepartment of Infectious Diseases, Robert Koch Institute, Berlin, Germany.ORCID 0000-0003-1544-9903
Christian DrostenCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0001-7923-0519
Roland LausterSi-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.
Nils LachmanInstitute for Transfusion Medicine, Tissue Typing Laboratory, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-2081-3098
Leif-Erik SanderDepartment of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-0476-9947
Victor M CormanCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0002-3605-0136
Jobst RöhmelDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-1535-8852
Lil Meyer-ArndtSi-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-7909-020X
Andreas ThielSi-M/"Der Simulierte Mensch," a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-5515-4002
Claudia Giesecke-ThielMax Planck Institute for Molecular Genetics, Berlin, Germany.ORCID 0000-0002-5927-7018
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functional relevance of preexisting cross-immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we show that human endemic coronavirus (HCoV)–reactive and SARS-CoV-2–cross-reactive CD4
Indexed as
AdultAgedAged, 80 and overAge FactorsAsymptomatic DiseasesBNT162 VaccineCD3 ComplexCD4-Positive T-LymphocytesCOVID-19COVID-19 VaccinesCross ReactionsFemaleHumansImmunityImmunodominant EpitopesMaleBNT162 VaccineCD3 ComplexCOVID-19 VaccinesImmunodominant EpitopesPeptide FragmentsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2
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Textfull text, public
LicenceCC BY
measurements read51
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.