ArticleProceedings of the National Academy of Sciences of the United States of America2021
Semiempirical method for examining asynchronicity in metal-oxido-mediated C-H bond activation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A Mononuclear Ruthenium(V)-Imido Complex With Hydrogen Bonding in the Second Coordination Sphere Forming Aziridines Without N-Substituents From Alkenes in Water.Angewandte Chemie (International ed. in English) · 2026Article
- High-Valent Late Transition Metal-Oxo Complexes: Breaking Boundaries at the Oxo Wall and Beyond.Chemical reviews · 2026Review
- Review
- Thermodynamic Principles Behind Mechanisms and Reactivities: Hydrogen Atom Abstraction and Related Radical Reactions.Accounts of chemical research · 2026Article
- Distinct hydrogen atom transfer and radical capture reactivity of copper(iii) OH/F complexes enables site-selective C(spChemical science · 2026Article
- C(spJournal of the American Chemical Society · 2025Article
- Basicity-Controlled C-H Bond Activation by a Structurally Characterized Ni(III)-Hydroxo Complex.Journal of the American Chemical Society · 2025Article
- Disentangling Driving Force Effects, Polar Effects,Journal of the American Chemical Society · 2025Article
- A 5,000-fold increase in the HAT reactivity of a nonheme FeProceedings of the National Academy of Sciences of the United States of America · 2025Article
- 10-Fold Increase in Hydrogen Atom Transfer Reactivity for a Series ofJournal of the American Chemical Society · 2025Article
- Article
- Molecular Simulation Analysis of Polyurethane Molecular Structure under External Electric Field.Molecules (Basel, Switzerland) · 2024Article
- Axial Ligation Impedes Proton-Coupled Electron-Transfer Reactivity of a Synthetic Compound-I Analogue.Journal of the American Chemical Society · 2024Article
- NMR and Mössbauer Studies Reveal a Temperature-Dependent Switch fromJournal of the American Chemical Society · 2024Article
- Polar Effects in Hydrogen Atom Transfer Reactions from a Proton-Coupled Electron Transfer (PCET) Perspective: Abstractions from Toluenes.The Journal of organic chemistry · 2023Article
- Reconciling Imbalanced and Nonadiabatic Reactivity in Transition Metal-Oxo-Mediated Concerted Proton Electron Transfer (CPET).The journal of physical chemistry letters · 2023Article
- The role of basicity in selective C-H bond activation by transition metal-oxidos.Dalton transactions (Cambridge, England : 2003) · 2023Review
- Variable temperature kinetic isotope effects demonstrate extensive tunnelling in the C-H activation reactivity of a transition metal-oxo complex.Chemical communications (Cambridge, England) · 2023Article
- Independent Tuning of the pInorganic chemistry · 2023Article
- Selective C-H Bond Cleavage with a High-Spin FeMolecules (Basel, Switzerland) · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
The oxidation of substrates via the cleavage of thermodynamically strong C-H bonds is an essential part of mammalian metabolism. These reactions are predominantly carried out by enzymes that produce high-valent metal-oxido species, which are directly responsible for cleaving the C-H bonds. While much is known about the identity of these transient intermediates, the mechanistic factors that enable metal-oxido species to accomplish such difficult reactions are still incomplete. For synthetic metal-oxido species, C-H bond cleavage is often mechanistically described as synchronous, proton-coupled electron transfer (PCET). However, data have emerged that suggest that the basicity of the M-oxido unit is the key determinant in achieving enzymatic function, thus requiring alternative mechanisms whereby proton transfer (PT) has a more dominant role than electron transfer (ET). To bridge this knowledge gap, the reactivity of a monomeric Mn
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