Evidence map›Paper›PMID 34465614›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2021

B-Cell Compartmental Features and Molecular Basis for Therapy in Autoimmune Disease.

Chao Zhang, Tian-Xiang Zhang, Ye Liu, Dongmei Jia, Pei Zeng, Chen Du, Meng Yuan, Qiang Liu, Yongjun Wang, Fu-Dong Shi

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05414487 (Exploring the Effects of B Cell Depletion With Ofatumumab on Immune Cells and Meningeal Lymphatic Drainage in Patients With Demyelinating Diseases - a Prospective Observational Study), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05414487 unknown statusnot on this mapstarted 2022, after this paper: background citation

Exploring the Effects of B Cell Depletion With Ofatumumab on Immune Cells and Meningeal Lymphatic Drainage in Patients With Demyelinating Diseases - a Prospective Observational Study

TypeobservationalSponsorTianjin Medical University General HospitalRan2022 to 2024Enrolled34ConditionsMultiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, Demyelinating Diseases of the Central Nervous SystemArmsOfatumumab
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. High Frequency of Circulating IL-4RJournal of clinical and translational hepatology · 2026
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  9. Review
  10. Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chao ZhangFrom the China National Clinical Research Center for Neurological Diseases (C.Z., Y.W., F.-D.S.), Beijing Tiantan Hospital, Capital Medical University; and Department of Neurology (C.Z., T.-X.Z., Y.L., D.J., P.Z., C.D., M.Y., Q.L., F.-D.S.), Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin Medical University, China.
Tian-Xiang ZhangFrom the China National Clinical Research Center for Neurological Diseases (C.Z., Y.W., F.-D.S.), Beijing Tiantan Hospital, Capital Medical University; and Department of Neurology (C.Z., T.-X.Z., Y.L., D.J., P.Z., C.D., M.Y., Q.L., F.-D.S.), Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin Medical University, China.
Ye LiuFrom the China National Clinical Research Center for Neurological Diseases (C.Z., Y.W., F.-D.S.), Beijing Tiantan Hospital, Capital Medical University; and Department of Neurology (C.Z., T.-X.Z., Y.L., D.J., P.Z., C.D., M.Y., Q.L., F.-D.S.), Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin Medical University, China.
Dongmei JiaFrom the China National Clinical Research Center for Neurological Diseases (C.Z., Y.W., F.-D.S.), Beijing Tiantan Hospital, Capital Medical University; and Department of Neurology (C.Z., T.-X.Z., Y.L., D.J., P.Z., C.D., M.Y., Q.L., F.-D.S.), Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin Medical University, China.
Pei ZengFrom the China National Clinical Research Center for Neurological Diseases (C.Z., Y.W., F.-D.S.), Beijing Tiantan Hospital, Capital Medical University; and Department of Neurology (C.Z., T.-X.Z., Y.L., D.J., P.Z., C.D., M.Y., Q.L., F.-D.S.), Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin Medical University, China.
Chen DuFrom the China National Clinical Research Center for Neurological Diseases (C.Z., Y.W., F.-D.S.), Beijing Tiantan Hospital, Capital Medical University; and Department of Neurology (C.Z., T.-X.Z., Y.L., D.J., P.Z., C.D., M.Y., Q.L., F.-D.S.), Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin Medical University, China. fshi@ncrcnd.org.cn yongjunwang@ncrcnd.org.cn.
Meng YuanFrom the China National Clinical Research Center for Neurological Diseases (C.Z., Y.W., F.-D.S.), Beijing Tiantan Hospital, Capital Medical University; and Department of Neurology (C.Z., T.-X.Z., Y.L., D.J., P.Z., C.D., M.Y., Q.L., F.-D.S.), Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin Medical University, China.
Qiang LiuFrom the China National Clinical Research Center for Neurological Diseases (C.Z., Y.W., F.-D.S.), Beijing Tiantan Hospital, Capital Medical University; and Department of Neurology (C.Z., T.-X.Z., Y.L., D.J., P.Z., C.D., M.Y., Q.L., F.-D.S.), Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin Medical University, China.
Yongjun WangFrom the China National Clinical Research Center for Neurological Diseases (C.Z., Y.W., F.-D.S.), Beijing Tiantan Hospital, Capital Medical University; and Department of Neurology (C.Z., T.-X.Z., Y.L., D.J., P.Z., C.D., M.Y., Q.L., F.-D.S.), Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin Medical University, China.
Fu-Dong ShiFrom the China National Clinical Research Center for Neurological Diseases (C.Z., Y.W., F.-D.S.), Beijing Tiantan Hospital, Capital Medical University; and Department of Neurology (C.Z., T.-X.Z., Y.L., D.J., P.Z., C.D., M.Y., Q.L., F.-D.S.), Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin Medical University, China. fshi@ncrcnd.org.cn yongjunwang@ncrcnd.org.cn.
National Clinical Research Center for Digestive Diseases · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesTo assess the molecular landscape of B-cell subpopulations across different compartments in patients with neuromyelitis optica spectrum disorder (NMOSD).

methodsWe performed B-cell transcriptomic profiles via single-cell RNA sequencing across CSF, blood, and bone marrow in patients with NMOSD.

resultsAcross the tissue types tested, 4 major subpopulations of B cells with distinct signatures were identified: naive B cells, memory B cells, age-associated B cells, and antibody-secreting cells (ASCs). NMOSD B cells show proinflammatory activity and increased expression of chemokine receptor genes ( DISCUSSION: B cells are compartmentally fine tuned toward autoreactivity in NMOSD and become hyperreactive to type I interferon. Inhibition of type I interferon pathway may provide a new therapeutic avenue for NMOSD.

Indexed as

TranscriptomeAdultAquaporin 4B-LymphocytesBone MarrowHumansImmunologic FactorsMemory B CellsNeuromyelitis OpticaSequence Analysis, RNAAQP4 protein, humanAquaporin 4Immunologic Factors

Identifiers

PMID34465614
PMCPMC8409132
OpenAlexW3198000461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.