ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Inner Hemispheric and Interhemispheric Connectivity Balance in the Human Brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Clinical and MRI substrates of Symbol Digit Modalities Test impairment in multiple sclerosis patients with an adult- and late-onset.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Mapping Human Corpus Callosum Connectivity With Diffusion Spectrum Imaging: A Deterministic Tractography Approach.Brain and behavior · 2026Article
- Weighting the structural connectome: Exploring its impact on network properties and predicting cognitive performance in the human brain.Network neuroscience (Cambridge, Mass.) · 2024Article
- Conservation of structural brain connectivity in people with multiple sclerosis.Network neuroscience (Cambridge, Mass.) · 2024Article
- Dynamic network analysis of electrophysiological task data.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Multi-channel recordings reveal age-related differences in the sleep of juvenile and adult zebra finches.Scientific reports · 2023Article
- Genetic architecture of the white matter connectome of the human brain.Science advances · 2023Article
- Expanding connectomics to the laminar level: A perspective.Network neuroscience (Cambridge, Mass.) · 2023Article
- Disrupted interhemispheric coordination of sensory-motor networks and insula in major depressive disorder.Frontiers in neuroscience · 2023Article
- Reduced homotopic interhemispheric connectivity in psychiatric disorders: evidence for both transdiagnostic and disorder specific features.Psychoradiology · 2022Review
- A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming.Nature communications · 2022Article
- Functional cortical associations and their intraclass correlations and heritability as revealed by the fMRI Human Connectome Project.Experimental brain research · 2022Article
- The effect of home-based transcranial direct current stimulation in cognitive performance in fibromyalgia: A randomized, double-blind sham-controlled trial.Frontiers in human neuroscience · 2022Article
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Authors and funding
3 authors.
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Abstract
The connectome of the brain has a great impact on the function of the brain as the structure of the connectome affects the speed and efficiency of information transfer. As a highly energy-consuming organ, an efficient network structure is essential. A previous study has shown consistent overall brain connectivity across a large variety of species. This connectivity conservation was explained by a balance between interhemispheric and intrahemispheric connections; that is, spices with highly connected hemispheres appear to have weaker interhemisphere connections. This study examines this connectivity trade-off in the human brain using diffusion-based tractography and network analysis in the Human Connectome Project (970 subjects, 527 female). We explore the biological origins of this phenomenon, heritability, and the effect on cognitive measures.The proportion of commissural fibers in the brain had a negative correlation to hemispheric efficiency, pointing to a trade-off between inner hemispheric and interhemispheric connectivity. Network hubs including anterior and middle cingulate cortex, superior frontal areas, medial occipital areas, the parahippocampal gyrus, post- and precentral gyri, and the precuneus had the strongest contribution to this phenomenon. Other results show a high heritability as well as a strong connection to crystalized intelligence. This work presents cohort-based network analysis research, spanning a large variety of samples and exploring the overall architecture of the human connectome. Our results show a connectivity conservation phenomenon at the base of the overall brain network architecture. This network structure may explain much of the functional, behavioral, and cognitive variability among different brains.
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