ReviewClinical nutrition (Edinburgh, Scotland)2022
Influence of reduced muscle mass and quality on ventilator weaning and complications during intensive care unit stay in COVID-19 patients.
Review in Clinical nutrition (Edinburgh, Scotland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 7 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 7 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Prevalence and prognosis of sarcopenia in acute COVID-19 and long COVID: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Exploring the association between computed tomography (CT)-derived skeletal muscle mass and short- and long-term mortality in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Impact of sarcopenia and frailty on outcomes of patients with sepsis or septic shock: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Which vertebral level should be used to calculate sarcopenia in covid-19 patients? A systematic review and meta-analysis.Clinical nutrition ESPEN · 2023Pooled it
- Prevalence and clinical implications of abnormal body composition phenotypes in patients with COVID-19: a systematic review.The American journal of clinical nutrition · 2023Pooled it
- Prevalence and mortality risk of low skeletal muscle mass in critically ill patients: an updated systematic review and meta-analysis.Frontiers in nutrition · 2023Pooled it
- Prevalence of Sarcopenia in Patients With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in a hamster model of COVID-19.Gut microbes · 2025Article
- Physical activity during COVID-19 pandemic: A 5-year retrospect.Sports medicine and health science · 2025Review
- Article
- An Analysis Between Body Composition and Vertigo Post-Coronavirus Disease 2019 Patients.International archives of otorhinolaryngology · 2025Article
- Sarcopenia, myosteatosis and inflammation are independent prognostic factors of SARS-CoV-2 pneumonia patients admitted to the ICU.Scientific reports · 2025Article
- The effect of pre-existing sarcopenia on outcomes of critically ill patients treated for COVID-19.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- Skeletal Muscle Mass Loss Leads to Prolonged Mechanical Ventilation and Higher Tracheotomy Rates in Critically Ill Patients.Journal of clinical medicine · 2024Article
- Acute Sarcopenia: Mechanisms and Management.Nutrients · 2024Review
- Thigh muscle mass evaluated by point-of-care ultrasound is associated with short-term mortality in patients with sepsis in the emergency department.Scientific reports · 2024Observational
- Sarcopenia and Mortality in Critically Ill COVID-19 Patients.Life (Basel, Switzerland) · 2023Review
- Radiologic Features of T10 Paravertebral Muscle Sarcopenia: Prognostic Factors in COVID-19.Journal of clinical medicine research · 2023Article
- The Effects of a Pulmonary Rehabilitation Program in Severe and Critical COVID-19 Disease: A Prospective Observational Study.Journal of clinical practice and research · 2023Article
- The association between reduced calf and mid-arm circumferences and ICU mortality in critically ill COVID-19 patients.Clinical nutrition ESPEN · 2023Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsSarcopenia, a loss of muscle mass, quality and function, which is particularly evident in respiratory muscles, has been associated with many clinical adverse outcomes. In this study, we aimed at evaluating the role of reduced muscle mass and quality in predicting ventilation weaning, complications, length of intensive care unit (ICU) and of hospital stay and mortality in patients admitted to ICU for SARS-CoV-2-related pneumonia.
methodsThis was an observational study based on a review of medical records of all adult patients admitted to the ICU of a tertiary hospital in Milan and intubated for SARS-CoV-2-related pneumonia during the first wave of the COVID-19 pandemic. Muscle mass and quality measurement were retrieved from routine thoracic CT scans, when sections passing through the first, second or third lumbar vertebra were available.
resultsA total of 81 patients were enrolled. Muscle mass was associated with successful extubation (OR 1.02, 95% C.I. 1.00-1.03, p = 0.017), shorter ICU stay (OR 0.97, 95% C.I. 0.95-0.99, p = 0.03) and decreased hospital mortality (HR 0.98, 95% C.I. 0.96-0.99, p = 0.02). Muscle density was associated with successful extubation (OR 1.07, 95% C.I. 1.01-1.14; p = 0.02) and had an inverse association with the number of complications in ICU (Β -0.07, 95% C.I. -0.13 - -0.002, p = 0.03), length of hospitalization (Β -1.36, 95% C.I. -2.21 - -0.51, p = 0.002) and in-hospital mortality (HR 0.88, 95% C.I. 0.78-0.99, p = 0.046).
conclusionsLeveraging routine CT imaging to measure muscle mass and quality might constitute a simple, inexpensive and powerful tool to predict survival and disease course in patients with COVID-19. Preserving muscle mass during hospitalisation might have an adjuvant role in facilitating remission from COVID-19.
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