ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2021
An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Altered neural activities during emotion regulation in depression: a meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Characterization of neural networks involved in transdiagnostic emotion dysregulation from a pilot randomized controlled trial of a neurostimulation-enhanced behavioral intervention.Psychiatry research. Neuroimaging · 2024Trial
- Integrating EEG and fMRI in naturalistic paradigms: Advances in understanding mental disorders-a decade study in review (2014-2024).Dialogues in clinical neuroscience · 2026Review
- Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Symptom severity, neighborhood crime, and neural correlates of reappraisal in patients with major depression and social anxiety.Psychological medicine · 2026Article
- Functional Brain Activity Associated With Intermittent Rhythmic Delta/Theta Activity: A Transdiagnostic Electroencephalography-Functional Magnetic Resonance Imaging Resting-State Study.Biological psychiatry global open science · 2026Article
- Exploration of the Value of Optical Coherence Tomography (OCT) and OCT Angiography in Differentiating Between Major Depressive Disorder and Borderline Personality Disorder.International journal of methods in psychiatric research · 2025Article
- Mediation and Interaction of Cognitive Reappraisal in the Relationship Between Depression and Social Pain Among College Students.Psychology research and behavior management · 2025Article
- Update on the Neurobiology of Borderline Personality Disorder: A Review of Structural, Resting-State and Task-Based Brain Imaging Studies.Current psychiatry reports · 2024Review
- The impact of neural emotion reactivity and regulation on the association between depression and suicide ideation in high-risk adults.Journal of affective disorders · 2024Article
- Borderline personality disorder: a comprehensive review of diagnosis and clinical presentation, etiology, treatment, and current controversies.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Dynamic fronto-amygdalar interactions underlying emotion-regulation deficits in women at higher weight.Obesity (Silver Spring, Md.) · 2023Article
- Personality characteristics, defense styles, borderline symptoms, and non-suicidal self-injury in first-episode major depressive disorder.Frontiers in psychology · 2023Article
- The plasticity of ChatGPT's mentalizing abilities: personalization for personality structures.Frontiers in psychiatry · 2023Article
- Borderline Personality Disorder: Updates in a Postpandemic World.Focus (American Psychiatric Publishing) · 2022Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOne common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation impairments are underpinned by shared or distinct neurobiological alterations.
methodsWe contrasted the neural correlates of negative emotion regulation across an adult sample of BPD patients (n = 19), MDD patients (n = 20), and healthy controls (HCs; n = 19). Emotion regulation was assessed using an established functional magnetic resonance imaging cognitive reappraisal paradigm. We assessed both task-related activations and modulations of interregional connectivity.
resultsWhen compared to HCs, patients with BPD and MDD displayed homologous decreased activation in the right ventrolateral prefrontal cortex (vlPFC) during cognitive reappraisal. In addition, the MDD group presented decreased activations in other prefrontal areas (i.e., left dorsolateral and bilateral orbitofrontal cortices), while the BPD group was characterized by a more extended pattern of alteration in the connectivity between the vlPFC and cortices of the visual ventral stream during reappraisal.
conclusionsThis study identified, for the first time, a shared neurobiological contributor to emotion regulation deficits in MDD and BPD characterized by decreased vlPFC activity, although we also observed disorder-specific alterations. In MDD, results suggest a primary deficit in the strength of prefrontal activations, while BPD is better defined by connectivity disruptions between the vlPFC and temporal emotion processing regions. These findings substantiate, in neurobiological terms, the different profiles of emotion regulation alterations observed in these disorders.
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