Evidence map›Paper›PMID 34465327›Full record

Trial reportMalaria journal2021

Effect of a single dose of oral azithromycin on malaria parasitaemia in children: a randomized controlled trial.

Boubacar Coulibaly, Ali Sié, Clarisse Dah, Mamadou Bountogo, Mamadou Ouattara, Adama Compaoré, Moustapha Nikiema, Jérôme Nankoné Tiansi, Nestor Dembélé Sibiri, Jessica M Brogdon and 5 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Malaria journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03676751 (Gut and Azithromycin Mechanisms in Infants and Neonates), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03676751 phase4completednot on this map

Gut and Azithromycin Mechanisms in Infants and Neonates

TypeinterventionalSponsorUniversity of California, San FranciscoRan2019 to 2020Enrolled500ConditionsChild Growth, Diversity of Microbiome, Child Mortality, Resistance BacterialArmsAzithromycin, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Boubacar CoulibalyCentre de Recherche en Santé de Nouna, Nouna, Burkina Faso.
Ali SiéCentre de Recherche en Santé de Nouna, Nouna, Burkina Faso.
Clarisse DahCentre de Recherche en Santé de Nouna, Nouna, Burkina Faso.
Mamadou BountogoCentre de Recherche en Santé de Nouna, Nouna, Burkina Faso.
Mamadou OuattaraCentre de Recherche en Santé de Nouna, Nouna, Burkina Faso.
Adama CompaoréCentre de Recherche en Santé de Nouna, Nouna, Burkina Faso.
Moustapha NikiemaCentre de Recherche en Santé de Nouna, Nouna, Burkina Faso.
Jérôme Nankoné TiansiCentre de Recherche en Santé de Nouna, Nouna, Burkina Faso.
Nestor Dembélé SibiriCentre de Recherche en Santé de Nouna, Nouna, Burkina Faso.
Jessica M BrogdonFrancis I Proctor Foundation, University of California, San Francisco, 490 Illinois St, Floor 2, San Francisco, CA, 94143, USA.
Elodie LebasFrancis I Proctor Foundation, University of California, San Francisco, 490 Illinois St, Floor 2, San Francisco, CA, 94143, USA.
Thuy DoanFrancis I Proctor Foundation, University of California, San Francisco, 490 Illinois St, Floor 2, San Francisco, CA, 94143, USA.
Travis C PorcoFrancis I Proctor Foundation, University of California, San Francisco, 490 Illinois St, Floor 2, San Francisco, CA, 94143, USA.
Thomas M LietmanFrancis I Proctor Foundation, University of California, San Francisco, 490 Illinois St, Floor 2, San Francisco, CA, 94143, USA.
Catherine E OldenburgFrancis I Proctor Foundation, University of California, San Francisco, 490 Illinois St, Floor 2, San Francisco, CA, 94143, USA. catherine.oldenburg@ucsf.edu.ORCID http://orcid.org/0000-0002-0763-399X
Centre de Recherche en Santé de Nouna · BFUniversity of California, San Francisco · US

Funding

Bill and Melinda Gates Foundation OPP1187628Research to Prevent Blindness Research to Prevent Blindness
6 · The paper itself

Abstract

backgroundAzithromycin has recently been shown to reduce all-cause childhood mortality in sub-Saharan Africa. One potential mechanism of this effect is via the anti-malarial effect of azithromycin, which may help treat or prevent malaria infection. This study evaluated short- and longer-term effects of azithromycin on malaria outcomes in children.

methodsChildren aged 8 days to 59 months were randomized in a 1:1 fashion to a single oral dose of azithromycin (20 mg/kg) or matching placebo. Children were evaluated for malaria via thin and thick smear and rapid diagnostic test (for those with tympanic temperature ≥ 37.5 °C) at baseline and 14 days and 6 months after treatment. Malaria outcomes in children receiving azithromycin versus placebo were compared at each follow-up timepoint separately.

resultsOf 450 children enrolled, 230 were randomized to azithromycin and 220 to placebo. Children were a median of 26 months and 51% were female, and 17% were positive for malaria parasitaemia at baseline. There was no evidence of a difference in malaria parasitaemia at 14 days or 6 months after treatment. In the azithromycin arm, 20% of children were positive for parasitaemia at 14 days compared to 17% in the placebo arm (P = 0.43) and 7.6% vs. 5.6% in the azithromycin compared to placebo arms at 6 months (P = 0.47).

conclusionsAzithromycin did not affect malaria outcomes in this study, possibly due to the individually randomized nature of the trial. Trial registration This study is registered at clinicaltrials.gov (NCT03676751; registered 19 September 2018).

Indexed as

Administration, OralAntimalarialsAzithromycinFemaleHumansInfantInfant, NewbornMalariaMaleParasitemiaAntimalarialsAzithromycinAzithromycinBurkina FasoMalariaRandomized controlled trial

Identifiers

PMID34465327
PMCPMC8407066
OpenAlexW3198234701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.