ArticlePharmaceutical biology2021
Hepatoprotective effect and metabonomics studies of radix gentianae in rats with acute liver injury.
Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Protective effects and metabolomics analysis of dihydromyricetin on cyclophosphamide-induced hepatotoxicity in mice.Pharmaceutical science advances · 2025Article
- Integration of bile proteomics and metabolomics analyses reveals novel insights into different types of gallstones in a high-altitude area.BMC gastroenterology · 2024Article
- Study on the mechanism of hepatotoxicity of Aucklandiae radix through liver metabolomics and network pharmacology.Toxicology research · 2024Article
- The anti-cholestatic effects ofFrontiers in pharmacology · 2024Article
- Multi-omics Analysis Reveals the Crucial Mediators of DJB in the Treatment of Type 2 Diabetes.Obesity surgery · 2023Article
- Serum metabolomics strategy for investigating the hepatotoxicity induced by different exposure times and doses ofRSC advances · 2023Article
- Rhoifolin Alleviates Alcoholic Liver DiseaseFrontiers in pharmacology · 2022Article
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Authors and funding
6 authors.
Funding
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Abstract
contextAs a well-known traditional Chinese medicine for protecting the liver, the mechanism of Radix Gentianae (RG) remains unclear.
objectiveThe hepatoprotective effect and metabonomics of RG were studied to explore the molecular and metabolic mechanisms of RG protecting the liver. MATERIALS AND
methodsSprague-Dawley rats were divided into control and model group (
resultsDifferent doses of RG can significantly decrease the levels of AST, ALT, TNF-α, MCP-1, IL-6 and MDA, and increase the levels of SOD, GSH, and GSH-PX in rats with liver injury (
conclusionRG demonstrated a good ability to protect the liver and improving endogenous metabolism in rats with liver injury. This can help us understand the mechanism of RG and more clinical verifications were inspired.
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