Evidence map›Paper›PMID 34465250›Full record

ArticleJournal of psychopharmacology (Oxford, England)2021

Three regulatory compliant test systems show no signs of MDMA-related genotoxicity.

Isaac Victor Cohen, Laken Barber, Tyson Paul Dubnicka, Sara Beth Hurtado, Sarah Ann Tincher, Leon Frank Stankowski, Berra Yazar-Klosinski

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Isaac Victor CohenClinical Pharmacology and Therapeutics (CPT) Postdoctoral Training Program, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1827-2429
Laken BarberDivision of Biochemistry, Hawai'i Pacific University, Honolulu, Hawaii.ORCID 0000-0002-6551-6986
Tyson Paul DubnickaCharles River Laboratories, Mattawan, MI, USA.
Sara Beth HurtadoCharles River Laboratories, Skokie, IL, USA.
Sarah Ann TincherCharles River Laboratories, Skokie, IL, USA.
Leon Frank StankowskiCharles River Laboratories, Skokie, IL, USA.
Berra Yazar-KlosinskiExecutive Department, Multidisciplinary Association for Psychedelic Studies, San Jose, CA, USA.
Charles River Laboratories (United States) · USHawaii Pacific University · USMultidisciplinary Association for Psychedelic Studies · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3,4 Methylenedioxymethamphetamine (MDMA)-assisted therapy has been recently found to be highly effective for treatment of posttraumatic stress disorder (PTSD). Previous studies have been inconclusive in elucidating potential MDMA genotoxicity. We performed three regulatory compliant studies to investigate the potential of genotoxic effects of MDMA treatment in humans: (1) an

Indexed as

AnimalsCHO CellsChromosome AberrationsCricetulusEscherichia coliFemaleMaleMutagenicity TestsNeurotransmitter AgentsN-Methyl-3,4-methylenedioxyamphetamineRatsRats, Sprague-DawleySalmonella typhimuriumStress Disorders, Post-TraumaticNeurotransmitter AgentsN-Methyl-3,4-methylenedioxyamphetamine3,4-MethylenedioxymethamphetamineGenotoxicityMDMAPTSDToxicology

Identifiers

PMID34465250
PMCPMC8600592
OpenAlexW3197754443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.