Evidence map›Paper›PMID 34465229›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Amyloid-

Emily C Peters, Michael T Gee, Lukas N Pawlowski, Allison M Kath, Felipe D Polk, Christopher J Vance, Juliana L Sacoman, Paulo W Pires

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  4. Article
  5. Review
  6. Amyloid β alters vascular CaThe Journal of physiology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Lysosomal TRPML1 triggers global CaFrontiers in physiology · 2024
    Article
  13. Article
  14. Cracking the Endothelial Calcium (CaInternational journal of molecular sciences · 2023
    Review
  15. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Emily C PetersDepartment of Physiology, University of Arizona College of Medicine Tucson, Tucson, AZ, USA.ORCID 0000-0001-7672-3510
Michael T GeeDepartment of Physiology, University of Arizona College of Medicine Tucson, Tucson, AZ, USA.
Lukas N PawlowskiDepartment of Physiology, University of Arizona College of Medicine Tucson, Tucson, AZ, USA.
Allison M KathDepartment of Physiology, University of Arizona College of Medicine Tucson, Tucson, AZ, USA.
Felipe D PolkDepartment of Physiology, University of Arizona College of Medicine Tucson, Tucson, AZ, USA.ORCID 0000-0001-7890-4737
Christopher J VanceDepartment of Physiology, University of Arizona College of Medicine Tucson, Tucson, AZ, USA.
Juliana L SacomanDepartment of Physiology, University of Arizona College of Medicine Tucson, Tucson, AZ, USA.
Paulo W PiresDepartment of Physiology, University of Arizona College of Medicine Tucson, Tucson, AZ, USA.ORCID 0000-0001-5972-4554
University of Arizona · US

Funding

Genetic Resource for Optical SignalingR24HL120847 · NHLBI · CORNELL UNIVERSITY · PI KOTLIKOFF, MICHAEL I. · 2014 to 2018
$3.1M
University of Arizona's Initiative for Maximizing Student Development (IMSD)T32GM139779 · NIGMS · UNIVERSITY OF ARIZONA · PI FRANS E TAX · 2022 to 2026
$2.9M
Cerebral functional hyperemia responses induced by capillary NMDA receptors are disrupted by amyloid-beta accumulationR00HL140106 · NHLBI · UNIVERSITY OF ARIZONA · PI PIRES, PAULO W · 2019 to 2021
$747k
NHLBI NIH HHS R00 HL140106NHLBI NIH HHS R24 HL120847NIGMS NIH HHS T32 GM139779
6 · The paper itself

Abstract

Transient increases in intracellular Ca

Indexed as

Calcium SignalingAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCalciumCerebral ArteriesDisease Models, AnimalEndothelium, VascularFemaleMaleMiceMice, TransgenicPeptide FragmentsReceptors, N-Methyl-D-AspartateAmyloid beta-Peptidesamyloid beta-protein (1-40)CalciumPeptide FragmentsReceptors, N-Methyl-D-Aspartateamyloid-βcerebral amyloid angiopathyendothelium Ca2+ signalingendothelium-dependent dilationN-methyl-D-aspartate receptor

Identifiers

PMID34465229
PMCPMC8721780
OpenAlexW3197110283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.