ArticleJournal of the American Heart Association2021
Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body Size.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review.European journal of epidemiology · 2024Pooled it
- Association of a 'three meals and sleep routine' lifestyle intervention with weight and metabolic health in children with obesity: a prospective, single-arm pilot study.Translational pediatrics · 2026Article
- The weight of timing: childhood-to-adulthood body mass index trajectories and the reversibility of coronary heart disease risk.Journal of thoracic disease · 2026Article
- Association of childhood-to-adulthood body size trajectories with cardiovascular risk and all cause mortality.International journal of obesity (2005) · 2026Article
- Early-life body mass index and adult fat distribution: a life-course Mendelian randomisation study.BMJ open · 2026Article
- Role of systemic and epicardial adipose tissue in cardiometabolic disease.Nature reviews. Cardiology · 2026Review
- A structural mean modeling Mendelian randomization approach to investigate the lifecourse effect of adiposity: applied and methodological considerations.American journal of epidemiology · 2026Article
- The causal role of genetically predicted obesity-related traits in heart failure: systematic review and meta-analysis of Mendelian randomization studies.Frontiers in cardiovascular medicine · 2026Review
- Relationship between childhood obesity and cardiovascular and cerebrovascular diseases: a study based on the combination of multiple databases.BMC public health · 2025Article
- Effects of childhood and adult height on later life cardiovascular disease risk estimated through Mendelian randomization.European journal of epidemiology · 2025Article
- Advances in Mendelian Randomization Studies of Obesity Over the Past Decade: Uncovering Key Genetic Mechanisms.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Article
- Childhood Adiposity and Risk of Major Clinical Heart Diseases in Adulthood: A Mendelian Randomization Study.Journal of the American Heart Association · 2024Article
- Characterizing the Causal Pathway From Childhood Adiposity to Right Heart Physiology and Pulmonary Circulation Using Lifecourse Mendelian Randomization.Journal of the American Heart Association · 2024Article
- Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study.eLife · 2023Article
- Age-specific effects of weight-based body size on fracture risk in later life: a lifecourse Mendelian randomisation study.European journal of epidemiology · 2023Article
- Effects of general and central adiposity on circulating lipoprotein, lipid, and metabolite levels in UK Biobank: A multivariable Mendelian randomization study.The Lancet regional health. Europe · 2022Article
- Phenotypic Causal Inference Using Genome-Wide Association Study Data: Mendelian Randomization and Beyond.Annual review of biomedical data science · 2022Review
- Article
- A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure.PLoS biology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Background Obesity is associated with long-term health consequences including cardiovascular disease. Separating the independent effects of childhood and adulthood obesity on cardiovascular disease risk is challenging as children with obesity typically remain overweight throughout the lifecourse. Methods and Results This study used 2-sample univariable and multivariable Mendelian randomization to estimate the effect of childhood body size both independently and after accounting for adult body size on 12 endpoints across the cardiovascular disease disease spectrum. Univariable analyses identified strong evidence of a total effect between genetically predicted childhood body size and increased risk of atherosclerosis, atrial fibrillation, coronary artery disease, heart failure, hypertension, myocardial infarction, peripheral artery disease, and varicose veins. However, evidence of a direct effect was weak after accounting for adult body size using multivariable Mendelian randomization, suggesting that childhood body size indirectly increases risk of these 8 disease outcomes via the pathway involving adult body size. Conclusions These findings suggest that the effect of genetically predicted childhood body size on the cardiovascular disease outcomes analyzed in this study are a result of larger body size persisting into adulthood. Further research is necessary to ascertain the critical timepoints where, if ever, the detrimental impact of obesity initiated in early life begins to become immutable.
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