Evidence map›Paper›PMID 34465025›Full record

ArticlemBio2021

The Mus musculus Papillomavirus Type 1 E7 Protein Binds to the Retinoblastoma Tumor Suppressor: Implications for Viral Pathogenesis.

Tao Wei, Miranda Grace, Aayushi Uberoi, James C Romero-Masters, Denis Lee, Paul F Lambert, Karl Munger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. E2 Tyrosine 102 Regulates MmuPV1 Pathogenesis In Vivo.Pathogens (Basel, Switzerland) · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tao Wei *McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Miranda Grace *Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Aayushi UberoiMcArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
James C Romero-MastersMcArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Denis LeeMcArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Paul F LambertMcArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Karl MungerDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA.
University of Wisconsin–Madison · USTufts University · US

Funding

Mouse Model of Human Papillomavirus PathogenesisR01CA228543 · NCI · TUFTS UNIVERSITY BOSTON · PI LAMBERT, PAUL F., MUNGER, KARL · 2019 to 2023
$2.3M
Understanding the Roles of the E6 and E7 Oncoproteins in MmuPV1 Induced CarcinogenesisF32CA254019 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ROMERO-MASTERS, JAMES · 2020 to 2022
$199k
NCI NIH HHS F32 CA254019NCI NIH HHS R01 CA228543
6 · The paper itself

Abstract

The species specificity of papillomaviruses has been a significant roadblock for performing

Indexed as

AnimalsCell Line, TumorDNA-Binding ProteinsHumansKeratinocytesMiceMice, NudeOncogene Proteins, ViralPapillomaviridaePapillomavirus E7 ProteinsPapillomavirus InfectionsProtein BindingRetinoblastoma Binding ProteinsTranscription FactorsDNA-Binding ProteinsOncogene Proteins, ViralPapillomavirus E7 ProteinsRb1 protein, mouseRetinoblastoma Binding ProteinsTranscription FactorsE7host-pathogen interactionsMmuPV1papillomavirusretinoblastoma tumor suppressortumor suppressor genesviral pathogenesis

Identifiers

PMID34465025
PMCPMC8406179
OpenAlexW3198890980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.