ArticleNature2021
Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies.
Abstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 220 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
220citing papers in PubMed, 1 pooled it
18.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
220 citing papers in PubMed, 1 synthesis or guideline pooled it, 323 citations in OpenAlex.
- Susceptibility of SARS-CoV-2 Omicron Variants to Therapeutic Monoclonal Antibodies: Systematic Review and Meta-analysis.Microbiology spectrum · 2022Pooled it
- Siglec-1-targeting single domain antibodies block or enhance pathogen binding to dendritic cells.The Journal of biological chemistry · 2026Article
- Identification of GRP78 as a novel host factor that facilitates zoonotic porcine deltacoronavirus internalization and replication via clathrin-mediated endocytosis.Journal of virology · 2026Article
- Concanavalin A targets phylogenetically conserved N-linked glycans on coronavirus spike proteins for broad-spectrum antiviral activity.Journal of virology · 2026Article
- TMPRSS2-mediated coronavirus spike activation and inhibition.Nature structural & molecular biology · 2026Article
- SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells.PLoS pathogens · 2026Article
- Decoding antibody response to MERS-CoV in wild dromedary camels.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses.Nature communications · 2026Article
- The Biological Role of Enveloped Virus Glycosylation and Its Interactions with Antiviral Lectins.Advances in experimental medicine and biology · 2026Review
- The regulatory mechanisms of SARS-CoV-2 N protein helicase and its annealing activity.iScience · 2025Article
- Increasing the Chemical Space of L-SIGN Specific Glycomimetics.Journal of medicinal chemistry · 2025Article
- From zoonotic spillover to endemicity: the broad determinants of human coronavirus tropism.mBio · 2025Review
- SAMHD1 promotes SARS-CoV-2 infection by enhancing HNF1-dependent ACE2 expression in lung epithelial cells.bioRxiv : the preprint server for biology · 2025Article
- Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice.Science translational medicine · 2025Article
- Molecular mechanisms of SARS-CoV-2 entry: implications for biomedical strategies.Microbiology and molecular biology reviews : MMBR · 2025Review
- Broadly Sarbecovirus-Neutralizing Antibodies Induced by Ancestral SARS-CoV-2 Infection.Viruses · 2025Article
- Organoid-based neutralization assays reveal a distinctive profile of SARS-CoV-2 antibodies and recapitulate the real-world efficacy.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Defining diverse spike-receptor interactions involved in SARS-CoV-2 entry: Mechanisms and therapeutic opportunities.Virology · 2025Review
160 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 7 institutions in 3 countries.
Florian A LemppVir Biotechnology, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6103-8078
Leah B SoriagaVir Biotechnology, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5852-741X
Martin Montiel-RuizVir Biotechnology, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6200-9578
Fabio BenigniHumabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Julia NoackVir Biotechnology, San Francisco, CA, USA.
Young-Jun ParkDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2901-6949
Siro BianchiHumabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-5100-8905
Alexandra C WallsDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9636-8330
John E BowenDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3590-9727
Jiayi ZhouVir Biotechnology, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4231-3422
Hannah KaiserVir Biotechnology, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3991-7401
Anshu JoshiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Maria AgostiniVir Biotechnology, San Francisco, CA, USA.
Marcel MeuryVir Biotechnology, San Francisco, CA, USA.
Exequiel DellotaVir Biotechnology, San Francisco, CA, USA.
Stefano JaconiHumabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0001-7527-4434
Elisabetta CameroniHumabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Javier Martinez-PicadoIrsiCaixa AIDS Research Institute, Badalona, Spain.ORCID http://orcid.org/0000-0002-4916-2129
Júlia Vergara-AlertIRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la UAB, Bellaterra (Cerdanyola del Vallès), Spain.
Nuria Izquierdo-UserosIrsiCaixa AIDS Research Institute, Badalona, Spain.
Herbert W VirginVir Biotechnology, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8580-7628
Antonio LanzavecchiaHumabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.ORCID http://orcid.org/0000-0002-3041-7240
David VeeslerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6019-8675
Lisa A PurcellVir Biotechnology, St Louis, MO, USA.
Amalio Telenti *Vir Biotechnology, San Francisco, CA, USA. atelenti@vir.bio.ORCID http://orcid.org/0000-0001-6290-7677
Davide Corti *Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland. dcorti@vir.bio.ORCID http://orcid.org/0000-0002-5797-1364
VIR Biotechnology (United States) · USVir Biotechnology (Switzerland) · CHUniversity of Washington · USCentre de Recerca en Sanitat Animal · ESIrsiCaixa · ESUniversitat de Vic - Universitat Central de Catalunya · ESWashington University in St. Louis · US
Funding
Unraveling the bat humoral immune response against zoonotic viruses to guide the design of next-generation therapeuticsDP1AI158186 · NIAID · UNIVERSITY OF WASHINGTON · PI VEESLER, DAVID · 2020 to 2024
$5.4MAcquisition of a high resolution, high throughput cryo-electron microscopeS10OD023476 · OD · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M · 2017 to 2017
$2.0MNIAID NIH HHS DP1 AI158186NIH HHS S10 OD023476Wellcome Trust
Abstract
SARS-CoV-2 infection-which involves both cell attachment and membrane fusion-relies on the angiotensin-converting enzyme 2 (ACE2) receptor, which is paradoxically found at low levels in the respiratory tract
Indexed as
Angiotensin-Converting Enzyme 2AnimalsAntibodies, NeutralizingCell Adhesion MoleculesCell FusionCell LineCricetinaeDC-Specific ICAM-3 Grabbing NonintegrinFemaleHumansLectinsLectins, C-TypeMembrane FusionReceptors, Cell SurfaceSARS-CoV-2Sialic Acid Binding Ig-like Lectin 1ACE2 protein, humanAngiotensin-Converting Enzyme 2Antibodies, NeutralizingCell Adhesion MoleculesCLEC4M protein, humanDC-Specific ICAM-3 Grabbing NonintegrinLectinsLectins, C-TypeReceptors, Cell SurfaceSialic Acid Binding Ig-like Lectin 1SIGLEC1 protein, humanSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.