Evidence map›Paper›PMID 34464847›Full record

ArticleBreast (Edinburgh, Scotland)2021

Positive effects of the enhanced recovery after surgery (ERAS) protocol in DIEP flap breast reconstruction.

N Gort, B G I van Gaal, H J P Tielemans, D J O Ulrich, S Hummelink

Registry-linked trialOpen access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast (Edinburgh, Scotland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07092475 (The Impact of Intraoperative Methadone on Postoperative Opioid Use), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07092475 phase3withdrawnnot on this mapstarted 2025, after this paper: background citation

The Impact of Intraoperative Methadone on Postoperative Opioid Use

TypeinterventionalSponsorUniversity of UtahRan2025 to 2025Enrolled0ConditionsBreast Cancer, Opioid UseArmsMethadon
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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  20. Journal of thoracic disease · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

N GortRadboud University Medical Center, Dept. of Plastic Surgery, Nijmegen, the Netherlands. Electronic address: nienke.gort@radboudumc.nl.
B G I van GaalHAN University of Applied Sciences, School of Health Studies, Nijmegen, the Netherlands; Radboud University Medical Center, Radboud Institute for Health Science, IQ Healthcare, Nijmegen, the Netherlands.
H J P TielemansRadboud University Medical Center, Dept. of Plastic Surgery, Nijmegen, the Netherlands.
D J O UlrichRadboud University Medical Center, Dept. of Plastic Surgery, Nijmegen, the Netherlands.
S HummelinkRadboud University Medical Center, Dept. of Plastic Surgery, Nijmegen, the Netherlands.
Radboud University Nijmegen · NLHAN University of Applied Sciences · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnhanced recovery after surgery protocols are successfully implemented in different surgical specialties, but a specific protocol for autologous breast reconstruction is missing. The aim of this study was to determine whether an enhanced recovery after surgery (ERAS) protocol contributes to a reduced length of stay without an increase in postoperative complications for patients undergoing a DIEP flap breast reconstruction. MATERIALS EN

methodsThe effect of the ERAS protocol was examined using a single-center patient-control study comparing two groups of patients. Patients who underwent surgery between November 2017 and November 2018 using the ERAS protocol were compared with a historical control group (pre-ERAS) who underwent surgery between November 2016 and November 2017. The primary outcome measure was hospital length of stay. Secondary outcome measures were postoperative pain and postoperative complications.

results152 patients were included (ERAS group, n = 73; control group, n = 79). Mean hospital length of stay was significantly shorter in the ERAS group than in the control group (5 vs. 6 days, p < 0.001). The average pain score was 1.73 in de the ERAS group compared to 2.17 in the control group (p = 0.032). There were no significant differences between the groups in postoperative complications. The ERAS group experienced less constipation (41 vs. 25 patients, p = 0.028).

conclusionAn enhanced recovery after surgery protocol contributes an accelerated postoperative recovery of patients undergoing a DIEP flap breast reconstruction. In this study a significant decrease was found in hospital length of stay, patient-reported pain score and adverse health issues.

Indexed as

Breast NeoplasmsEnhanced Recovery After SurgeryMammaplastyFemaleHumansLength of StayPostoperative ComplicationsAutologous breast reconstructionDIEP flapEnhanced recovery after surgeryERASFree flapMicrosurgery

Identifiers

PMID34464847
PMCPMC8406354
OpenAlexW3195021958

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.