ArticleNeuroscience2021
Voluntary Exercise Increases Neurogenesis and Mediates Forgetting of Complex Paired Associates Memories.
Article in Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Voluntary Exercise and Hippocampal Memory Enhancement: Decoding the Molecular Blueprint.Journal of molecular neuroscience : MN · 2026Review
- Exercise training promotes neurogenesis in the adult hippocampus with a particular focus on cell cycle regulation.Frontiers in sports and active living · 2026Review
- Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype.The international journal of neuropsychopharmacology · 2025Article
- Memory processing by hippocampal adult-born neurons.Neurobiology of learning and memory · 2025Review
- Amelioration of Chronic Ethanol Administration-Induced Learning and Memory Impairments by High-Intensity Interval Training (HIIT) and Ritalin.Brain and behavior · 2025Article
- Fear of Predators Suppresses Neurogenesis in the Brains of Wild Songbirds.Integrative organismal biology (Oxford, England) · 2025Article
- Article
- Neurogenesis-dependent remodeling of hippocampal circuits reduces PTSD-like behaviors in adult mice.Molecular psychiatry · 2024Article
- Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay.Molecular brain · 2024Article
- PAW, a cost-effective and open-source alternative to commercial rodent running wheels.HardwareX · 2024Article
- Sex in aging matters: exercise and chronic stress differentially impact females and males across the lifespan.Frontiers in aging neuroscience · 2024Article
- Ageing, Cognitive Decline, and Effects of Physical Exercise: Complexities, and Considerations from Animal Models.Brain plasticity (Amsterdam, Netherlands) · 2024Review
- Adult-born neurons add flexibility to hippocampal memories.Frontiers in neuroscience · 2023Review
- Brain-cell growth keeps mood disorders at bay.Nature · 2022Article
- Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved.Neurochemical research · 2022Review
- Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval.Scientific reports · 2022Article
- Image discrimination reversal learning is impaired by sleep deprivation in rats: Cognitive rigidity or fatigue?Frontiers in systems neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The hippocampus is a critical structure involved in many forms of learning and memory. It is also one of the only regions in the mammalian brain that continues to generate new neurons throughout adulthood. This process of adult neurogenesis may increase the plasticity of the hippocampus which could be beneficial for learning but has also been demonstrated to decrease the stability of previously acquired memories. Here we test whether exposure to voluntary running (which increases the production of new neurons) following the formation of a gradually acquired paired associates task will result in forgetting of this type of memory. We trained mice in a touchscreen-based object/location task and then increased neurogenesis using voluntary running. Our results indicate that running increased neurogenesis and resulted in poor recall of the previously established memory. When subsequently exposed to a reversal task we also show that running reduced the number of correction trials required to acquire the new task contingencies. This suggests that prior forgetting reduces perseveration on the now outdated memory. Together our results add to a growing body of literature which indicates the important role of adult neurogenesis in destabilizing previously acquired memories to allow for flexible encoding of new memories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.