ArticleJournal of the American Chemical Society2021
Copper-Catalyzed Cross-Coupling of Benzylic C-H Bonds and Azoles with Controlled
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Formal Markovnikov Hydroazolation of Alkenes via Reductive Activation of Alkylthianthrenium Salts.Journal of the American Chemical Society · 2026Article
- Copper-catalysed site-selective arylation of pyrazoles.Nature chemistry · 2026Article
- Unlocking azole chemical space via modular and regioselective N-alkylation.Nature chemistry · 2025Article
- Biocatalytic Alkylation of Ambident Nucleophiles Enables Selective N-Functionalization of Heterocycles and Late-Stage Modifications.Angewandte Chemie (International ed. in English) · 2025Article
- Evolving Landscape: Accounts of Academic-Industrial Collaborations in Chemistry Technology.ACS medicinal chemistry letters · 2025Review
- Copper-catalyzed C(spNature communications · 2025Article
- Ir(iii)/Ag(i)-catalyzed directly C-H amidation of arenes with OH-free hydroxyamides as amidating agents.RSC advances · 2024Article
- Mechanistic insights into radical formation and functionalization in copper/Chemical science · 2024Article
- Copper-Catalyzed Benzylic C-H Cross-Coupling Enabled by Redox Buffers: Expanding Synthetic Access to Three-Dimensional Chemical Space.Accounts of chemical research · 2023Article
- Accessing three-dimensional molecular diversity through benzylic C-H cross-coupling.Nature synthesis · 2023Article
- Polar Heterobenzylic C(spJournal of the American Chemical Society · 2023Article
- Copper-Catalyzed Hydroamination: Enantioselective Addition of Pyrazoles to Cyclopropenes.Journal of the American Chemical Society · 2023Article
- Benzylic C-H Esterification with Limiting C-H Substrate Enabled by Photochemical Redox Buffering of the Cu Catalyst.Journal of the American Chemical Society · 2023Article
- Azolation of Benzylic C-H Bonds via Photoredox-Catalyzed Carbocation Generation.Journal of the American Chemical Society · 2023Article
- Article
- Enantioselective Synthesis ofJournal of the American Chemical Society · 2022Article
- Traceless Benzylic C-H Amination via Bifunctional N-Aminopyridinium Intermediates.Angewandte Chemie (International ed. in English) · 2022Article
- Copper-catalyzed radical cascade reaction of simple cyclobutanes: synthesis of highly functionalized cyclobutene derivatives.Chemical science · 2022Article
- Radical C(sp3)-H functionalization and cross-coupling reactions.Nature reviews. Chemistry · 2022Article
- SuFExableThe Journal of organic chemistry · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Azoles are important motifs in medicinal chemistry, and elaboration of their structures via direct N-H/C-H coupling could have broad utility in drug discovery. The ambident reactivity of many azoles, however, presents significant selectivity challenges. Here, we report a copper-catalyzed method that achieves site-selective cross-coupling of pyrazoles and other N-H heterocycles with substrates bearing (hetero)benzylic C-H bonds. Excellent
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Registered trials
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