ArticleHuman brain mapping2021
Cannabis use impacts pre-stimulus neural activity in the visual cortices of people with HIV.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies.Current HIV/AIDS reports · 2024Pooled it
- Cannabis use by people with HIV is associated with an anti-inflammatory immunometabolic phenotype in monocyte-derived macrophages.Journal of neuroinflammation · 2026Article
- Neural oscillations serving abstract reasoning are differentially associated with inflammatory markers in people with HIV.Brain, behavior, and immunity · 2026Article
- Elevated neurotransmitter levels in people with HIV are associated with attention function.Neurobiology of disease · 2026Article
- Elevated inflammation in people with HIV is associated with aberrant neural oscillations serving selective attention.Journal of neuroinflammation · 2026Article
- Neural compensation in persons with HIV and marijuana use: Insights from a reorganized DMN.Network neuroscience (Cambridge, Mass.) · 2026Article
- Regular cannabis use modulates gamma functional connectivity with V1 during visual processing.NeuroImage · 2025Article
- Motor-Related Neural Dynamics are Modulated by Regular Cannabis Use Among People with HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Chronic cannabis use differentially modulates neural oscillations serving the manipulate versus maintain components of working memory processing.Neurobiology of disease · 2025Article
- Cannabis- and HIV-related perturbations to the cortical gamma dynamics supporting inhibitory processing.Brain communications · 2025Article
- Regular cannabis use modulates gamma activity in brain regions serving motor control.Journal of psychopharmacology (Oxford, England) · 2024Article
- Chronic Cannabis users exhibit altered oscillatory dynamics and functional connectivity serving visuospatial processing.Journal of psychopharmacology (Oxford, England) · 2024Article
- Chronic cannabis use alters the spontaneous and oscillatory gamma dynamics serving cognitive control.Human brain mapping · 2024Article
- Spontaneous cortical activity is altered in persons with HIV and related to domain-specific cognitive function.Brain communications · 2024Article
- Altered functional connectivity and oscillatory dynamics in polysubstance and cannabis only users during visuospatial processing.Psychopharmacology · 2023Article
- Imaging of Brain Structural and Functional Effects in People With Human Immunodeficiency Virus.The Journal of infectious diseases · 2023Review
- Article
- Regular cannabis use modulates the impact of HIV on the neural dynamics serving cognitive control.Journal of psychopharmacology (Oxford, England) · 2022Article
- Cannabis use impacts pre-stimulus neural activity in the visual cortices of people with HIV.Human brain mapping · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
People with HIV (PWH) use cannabis at a higher rate than the general population, but the influence on neural activity is not well characterized. Cannabis use among PWH may have a beneficial effect, as neuroinflammation is known to be a critical problem in PWH and cannabis use has been associated with a reduction in proinflammatory markers. Thus, it is important to understand the net impact of cannabis use on brain and cognitive function in PWH. In this study, we collected magnetoencephalographic (MEG) brain imaging data on 81 participants split across four demographically matched groups (i.e., PWH using cannabis, controls using cannabis, non-using PWH, and non-using controls). Participants completed a visuospatial processing task during MEG. Time-frequency resolved voxel time series were extracted to identify the dynamics of oscillatory and pre-stimulus baseline neural activity. Our results indicated strong theta (4-8 Hz), alpha (10-16 Hz), and gamma (62-72 Hz) visual oscillations in parietal-occipital brain regions across all participants. PWH exhibited significant behavioral deficits in visuospatial processing, as well as reduced theta oscillations and elevated pre-stimulus gamma activity in visual cortices, all of which replicate prior work. Strikingly, chronic cannabis use was associated with a significant reduction in pre-stimulus gamma activity in the visual cortices, such that PWH no longer statistically differed from controls. These results provide initial evidence that cannabis use may normalize some neural aberrations in PWH. This study fills an important gap in understanding the impact of cannabis use on brain and cognitive function in PWH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.