Evidence map›Paper›PMID 34464377›Full record

ArticlePLoS biology2021

TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.

Edward S Mocarski, Pratyusha Mandal

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Edward S MocarskiDepartment of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.ORCID 0000-0002-8362-9490
Pratyusha MandalDepartment of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Emory University · US

Funding

CYTOMEGALOVIRUS DNA REPLICATION AND RECOMBINATIONR01AI020211 · NIAID · STANFORD UNIVERSITY · PI EDWARD S MOCARSKI, EDWARD S. · 1985 to 2021
$5.9M
3-D Culture ModelsR21AI142507 · NIAID · EMORY UNIVERSITY · PI EDWARD S MOCARSKI, EDWARD S. · 2019 to 2020
$429k
NIAID NIH HHS R01 AI020211NIAID NIH HHS R21 AI142507
6 · The paper itself

Abstract

In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases.

Indexed as

ApoptosisTumor Necrosis Factor-alphaAnimalsCaspasesEmbryonic DevelopmentInflammationMiceReceptor-Interacting Protein Serine-Threonine KinasesCaspasesReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouseTumor Necrosis Factor-alpha

Identifiers

PMID34464377
PMCPMC8407551
OpenAlexW3197758443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.