Trial reportAmerican journal of respiratory and critical care medicine2021
Effect of Esophageal Pressure-guided Positive End-Expiratory Pressure on Survival from Acute Respiratory Distress Syndrome: A Risk-based and Mechanistic Reanalysis of the EPVent-2 Trial.
Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06119516 (Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients), which is not on this map. Cited by 69 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Guideline
- The Effect of Transpulmonary Pressure-Guided Positive End-Expiratory Pressure Titration on Pulmonary Arterial Compliance in Acute Respiratory Distress Syndrome Patients: A Single-Center, Randomized Controlled Pilot Pathophysiological Study.Critical care explorations · 2026Trial
- The impact of varying intraoperative oxygen concentrations on lung ultrasound scores and postoperative recovery among elderly patients residing in moderate altitude areas during laparoscopic surgery.Frontiers in physiology · 2026Trial
- Influence of ventilatory settings on pendelluft and expiratory muscle activity in hypoxemic patients resuming spontaneous breathing.Critical care (London, England) · 2025Trial
- Comparison of two transpulmonary pressure-based positive end-expiratory pressure titration strategies in acute respiratory distress syndrome: a randomized crossover study.Critical care (London, England) · 2025Trial
- Transpulmonary Pressure as a Predictor of Successful Lung Recruitment: Reanalysis of a Multicenter International Randomized Clinical Trial.Respiratory care · 2025Trial
- Ultra-lung-protective ventilation and biotrauma in severe ARDS patients on veno-venous extracorporeal membrane oxygenation: a randomized controlled study.Critical care (London, England) · 2022Trial
- Esophageal pressure monitoring and ECCO 2 R: a personalized approach to ultraprotective mechanical ventilation in ARDS patients.Medical gas research · 2026Article
- ARDS management beyond the guidelines: a practical physiology-based approach to individualized care.Intensive care medicine · 2026Review
- PEEP and alveolar recruitment after 60 years of acute respiratory distress syndrome.Intensive care medicine · 2026Review
- Near infrared enhanced palladium loaded siraitia grosvenorii carbon dots amplify mitophagy for acute lung injury immunotherapy.Bioactive materials · 2026Article
- Awake Prone Positioning in Non-Intubated Non-COVID-19 ARDS: A Comprehensive Review.Advances in respiratory medicine · 2026Review
- Right ventricular-protective ventilation in acute respiratory distress syndrome: phenotypes, monitoring and ventilatory management.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- A brain-lung circuit drives LPS-induced lung injury via sympathetic neutrophil axis.Journal of neuroinflammation · 2026Article
- Mechanical ventilation for ICU patient with obesity: current best practices and future directions.Intensive care medicine · 2026Review
- Article
- Positive end-expiratory pressure in pediatric acute respiratory distress syndrome: a narrative review.Translational pediatrics · 2026Review
- Setting PEEP in patients with COVID-19-related ARDS: a physiological comparison between methods.Intensive care medicine experimental · 2026Article
- Current Insights into Clinical, Molecular, and Therapeutic Approaches to Acute Respiratory Distress Syndrome.Medical sciences (Basel, Switzerland) · 2026Review
- Mechanical ventilation in ARDS: navigating the fine line with real-time monitoring.Critical care (London, England) · 2026Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
10 authors at 6 institutions in 3 countries.
Todd SargeDepartment of Anesthesia, Critical Care, and Pain Medicine and.
Elias Baedorf-KassisDivision of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Valerie Banner-GoodspeedDepartment of Anesthesia, Critical Care, and Pain Medicine and.
Victor NovackSoroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva, Israel.
Stephen H LoringDepartment of Anesthesia, Critical Care, and Pain Medicine and.
Michelle N GongMontefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
Deborah CookSt. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada; and.
Daniel TalmorDepartment of Anesthesia, Critical Care, and Pain Medicine and.
Jeremy R BeitlerCenter for Acute Respiratory Failure, Division of Pulmonary, Allergy, and Critical Care Medicine, NewYork-Presbyterian Hospital, College of Physicians and Surgeons, Columbia University, New York, New York.ORCID 0000-0003-0797-2374
EPVent-2 Study Group
Pain and Rehabilitation Medicine · USAlbert Einstein College of Medicine · USBeth Israel Deaconess Medical Center · USNewYork–Presbyterian Hospital · USSoroka Medical Center · ILSt. Joseph's Hospital · CA
Funding
Sub Project 2UM1HL108724 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LORING, STEPHEN H, TALMOR, DANIEL STUART · 2012 to 2014
$4.6MBreath stacking dyssynchrony in acute respiratory distress syndromeK23HL133489 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BEITLER, JEREMY R. · 2017 to 2021
$871kMeasuring lung stress to identify occult ventilation-induced lung injury in ARDSR21HL145506 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BEITLER, JEREMY R. · 2019 to 2020
$243kNHLBI NIH HHS K23 HL133489NHLBI NIH HHS R21 HL145506NHLBI NIH HHS UM1 HL108724
Abstract
PubMed holds no abstract for this paper.
Indexed as
SurvivalAdultEsophagusHumansImagery, PsychotherapyMaleMiddle AgedPositive-Pressure RespirationProspective StudiesRespiration, ArtificialRespiratory Distress SyndromeRisk FactorsVentilator-Induced Lung Injuryacute respiratory distress syndromemechanical ventilationpositive end-expiratory pressurerandomized controlled trialventilator-induced lung injury
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT06119516ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.