ReviewPeriodontology 20002021
Frailty, aging, and periodontal disease: Basic biologic considerations.
Review in Periodontology 2000, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 7 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- Oral Health Determinants of Frailty in Older Adults: An Umbrella Review of Systematic Reviews and Meta-Analyses.International dental journal · 2026Pooled it
- Multi-cohort evidence linking edentulism to frailty among older adults.Scientific reports · 2025Pooled it
- The Role of the Oral Microbiome in Periodontal Disease: A Systematic Review of Microbial Associations and Therapeutic Implications.Current microbiology · 2025Pooled it
- Inflammatory Association between Periodontal Disease and Systemic Health.Inflammation · 2025Pooled it
- Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Association between sleep-disordered breathing and periodontitis: a meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2023Pooled it
- Obesity and periodontitis: A systematic review and updated meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Identification of Drug Associated Factors for Gingival Disorders: A Real-World Pharmacovigilance Study.International dental journal · 2026Article
- Epigenetic mechanisms of gingival aging: biological basis, periodontal implications, and therapeutic perspectives.Odontology · 2026Review
- Diagnostic value of rising smoke sign on MRI: a characteristic finding of odontogenic maxillary sinusitis.Oral radiology · 2026Article
- Inhibition of CD38 by 78c Enhanced NADInternational journal of molecular sciences · 2026Article
- Ageing of the Oral Mucosa: Mechanisms and Consequences.International dental journal · 2026Review
- Myeloid-Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Article
- Association between periodontal and geriatric health: a cross-sectional study.Clinical oral investigations · 2026Article
- Screening for Periodontitis Using Blood Biomarkers and Demographic Data: A Machine Learning Study.Oral health & preventive dentistry · 2026Article
- Muscle weakness, greater fat mass, lower hematocrit levels, and advanced age in a diagnostic prediction model of periodontitis in adults with obesity: a cross-sectional study.BMC oral health · 2026Article
- Association of periodontitis with reduced kidney function and albuminuria in early chronic kidney disease: a population-based study.International journal of oral science · 2026Article
- Osteoimmunologic and Immune-Aging Signatures in Postmenopausal Women with Periodontitis and Low Bone Mineral Density: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Aging is associated with the development of disease. Periodontal disease is one of the many diseases and conditions that increase in prevalence with age. In addition to the traditional focus on individual age-related conditions, there is now a greater recognition that multisystem conditions such as frailty play an important role in the health of older populations. Frailty is a clinical condition in older adults that increases the risk of adverse health outcomes. Both frailty and periodontal disease are common chronic conditions in older populations and share several risk factors. There is likely a bidirectional relationship between periodontal disease and frailty. Comorbid systemic diseases, poor physical functioning, and limited ability to self-care in frail older people have been implicated as underlying the association between frailty and periodontal disease. In addition, both frailty and periodontal disease also have strong associations with inflammatory dysregulation and other age-related pathophysiologic changes that may similarly underlie their development and progression. Investigating age-related changes in immune cells that regulate inflammation may lead to a better understanding of age-related disease and could lead to therapeutic targets for the improved management of frailty and periodontal disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.