ReviewPeriodontology 20002021
The psychobiological links between chronic stress-related diseases, periodontal/peri-implant diseases, and wound healing.
Review in Periodontology 2000, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Influence of Psychological Stress and Stress-Related Disorders in the Treatment Outcome of Periodontitis: A Systematic Review and Meta-Analysis.Journal of clinical periodontology · 2025Pooled it
- Accuracy and primary stability of tapered or straight implants placed into fresh extraction socket using dynamic navigation: a randomized controlled clinical trial.Clinical oral investigations · 2022Trial
- Impact of war on oral health among the Gaza population: a comparative cross-sectional study.BMC oral health · 2026Article
- Evaluation of Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) Biomarker Concentrations in the Saliva of Patients with Periodontitis and Depression.Clinical and experimental dental research · 2026Article
- Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner.Gut microbes · 2025Article
- Chronic stress and the IL-10-mediated immunoregulatory loop in the pathogenesis of periodontitis.Clinical science (London, England : 1979) · 2025Review
- Evaluation of salivary cortisol levels in peri-implant diseases: An analytical observational study.Journal of advanced periodontology & implant dentistry · 2025Article
- Salivary chromogranin A levels in periodontal health status: a cross-sectional study evaluating clinical and psychological associations.BMC oral health · 2025Article
- Evidence for the association between psychological stress and peri-implant health among middle-aged and elderly adults: A systemic review.World journal of clinical cases · 2025Article
- The economic and societal impact of periodontal and peri-implant diseases.Periodontology 2000 · 2025Review
- Stress-induced hemostasis: mechanisms and implications for health.Annals of medicine and surgery (2012) · 2025Review
- Psychological Stress Reduces the Effectiveness of Periodontal Treatment: A Systematic Review.Journal of clinical medicine · 2025Review
- Influence of Psychological Stress on the Response to Periodontal Treatment: Protocol for a Systematic Review.JMIR research protocols · 2024Article
- Apelin Counteracts the Effects ofInternational journal of molecular sciences · 2024Article
- Improved new bone formation capacity of hyaluronic acid-bone substitute compound in rat calvarial critical size defect.BMC oral health · 2024Article
- Effects of restraint stress and surface treatments on the stability of titanium dental implant osseointegration in dogs: An in vivo comparative study.Journal of Taibah University Medical Sciences · 2024Article
- Bibliometric Analysis and Visualization of Clinical Trials on Psychological Stress and Oral Health (1967-2024).Cureus · 2024Review
- Moderating effect of negative emotion differentiation in chronic stress and fatigue among Chinese employees.Frontiers in psychology · 2024Article
- Mental Health and Oral Health in a Nationally Representative Cohort.Journal of dental research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Chronic stress is a relevant disease to periodontal practice, encompassing 25%-28% of the US population (American Psychological Association 2015). While it is well established that chronic psychologic stress can have significant deleterious systemic effects, only in recent decades have we begun to explore the biochemical, microbial, and physiologic impacts of chronic stress diseases on oral tissues. Currently, chronic stress is classified as a "risk indicator" for periodontal disease. However, as the evidence in this field matures with additional clinically controlled trials, more homogeneous data collection methods, and a better grasp of the biologic underpinnings of stress-mediated dysbiosis, emerging evidence suggests that chronic stress and related diseases (depression, anxiety) may be significant contributing factors in periodontal/peri-implant disease progression and inconsistent wound healing following periodontal-related therapeutics. Ideal solutions for these patients include classification of the disease process and de-escalation of chronic stress conditions through coping strategies. This paper also summarizes periodontal/implant-related therapeutic approaches to ensure predictable results for this specific patient subpopulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.