ReviewPeriodontology 20002021
Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome.
Review in Periodontology 2000, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 4 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Age-Related Differences in Oral Microbiota Among Obese Patients with Periodontitis: A Systematic Review.Nutrients · 2026Pooled it
- Inflammatory Association between Periodontal Disease and Systemic Health.Inflammation · 2025Pooled it
- The role of periodontitis in the development of atherosclerotic cardiovascular disease in participants with the components of metabolic syndrome: a systematic review and meta-analysis.Clinical oral investigations · 2024Pooled it
- Host insulin resistance caused byFrontiers in cellular and infection microbiology · 2023Pooled it
- Repurposing Metformin for periodontal disease management as a form of oral-systemic preventive medicine.Journal of translational medicine · 2023Trial
- The effect of antimicrobial photodynamic therapy on periodontal disease and glycemic control in patients with type 2 diabetes mellitus.Clinical oral investigations · 2023Trial
- Association between periodontitis and heart failure: Mechanisms and clinical implications (Review).Molecular medicine reports · 2026Review
- Dual-Biomarker Oral-Rinse Testing for aMMP-8 and Calprotectin: A Potential Adjunctive Tool for Risk Stratification and Interdisciplinary Referral in Periodontitis and Type 2 Diabetes.Bioengineering (Basel, Switzerland) · 2026Review
- Association of Subjective Oral Status and Oral Health Behaviours With a History of Systemic Disease Among Community-Dwelling Older Adults.Oral health & preventive dentistry · 2026Article
- RPS5 modulates inflammatory response and angiogenesis in coronary heart disease through NF-κB signaling activation.Molecular and cellular biochemistry · 2026Article
- Metabolic Syndrome and Periodontitis-From Shared Mechanisms to Interdisciplinary Care: A Narrative Review of Clinical Evidence.Journal of clinical medicine · 2026Review
- Metabolic Risk Signals in Periodontal Clinics: Cross-Sectional Associations of PISA with hs-CRP and HOMA-IR.Diagnostics (Basel, Switzerland) · 2026Article
- Preterm birth and birth weight extremes are associated with periodontal disease and tooth loss in the ARIC study.Scientific reports · 2026Article
- GLP-1 Receptor Agonists in Periodontology: Mechanisms, Clinical Evidence, and Implications for Care.Biomolecules · 2026Review
- The Actinobacteria-to-Proteobacteria (A/P) Ratio: A Novel Oral Microbial Marker for Metabolic Syndrome.International dental journal · 2026Article
- Diagnostic Potential of aMMP-8 PoCT in Oral Fluids: Insights from Periodontitis and Metabolic Syndrome Interplay.European journal of dentistry · 2026Article
- Oral-gut microbiome dysbiosis in obese smokers reveals compartment-specific shifts.AMB Express · 2026Article
- Multi-omics integration reveals ANXA6-high γδ T cell-endothelial communication as a potential link between periodontitis and MASLD.NPJ systems biology and applications · 2026Article
- Periodontitis and respiratory infections - exploring the oral-systemic link.Annals of medicine and surgery (2012) · 2026Article
- Metabolomic characteristics and mechanisms of subgingival plaque in MASLD patients with periodontitis.Metabolomics : Official journal of the Metabolomic Society · 2026Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
Periodontitis has been associated with many systemic diseases and conditions, including metabolic syndrome. Metabolic syndrome is a cluster of conditions that occur concomitantly and together they increase the risk of cardiovascular disease and double the risk of type 2 diabetes. In this review, we focus on the association between metabolic syndrome and periodontitis; however, we also include information on diabetes mellitus and cardiovascular disease, since these two conditions are significantly intertwined with metabolic syndrome. With regard to periodontitis and metabolic syndrome, to date, the vast majority of studies point to an association between these two conditions and also demonstrate that periodontitis can contribute to the development of, or can worsen, metabolic syndrome. Evaluating the effect of metabolic syndrome on the salivary microbiome, data presented herein support the hypothesis that the salivary bacterial profile is altered in metabolic syndrome patients compared with healthy patients. Considering periodontitis and these three conditions, the vast majority of human and animal studies point to an association between periodontitis and metabolic syndrome, diabetes, and cardiovascular disease. Moreover, there is evidence to suggest that metabolic syndrome and diabetes can alter the oral microbiome. However, more studies are needed to fully understand the influence these conditions have on each other.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.