Evidence map›Paper›PMID 34463919›Full record

SynthesisJournal of thrombosis and thrombolysis2022

Catheter directed compared to systemically delivered thrombolysis for pulmonary embolism: a systematic review and meta-analysis.

Ahmed K Pasha, Muhammad Umer Siddiqui, Muhammad Danial Siddiqui, Adnan Ahmed, Ammar Abdullah, Irbaz Riaz, M Hassan Murad, Haraldur Bjarnason, Waldemar E Wysokinski, Robert D McBane

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of thrombosis and thrombolysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  7. Article
  8. Observational
  9. Drivers and recent trends of hospitalisation costs related to acute pulmonary embolism.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  10. Review
  11. Article
  12. Observational
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  14. Article
  15. Article
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  18. Interventional therapies for pulmonary embolism.Nature reviews. Cardiology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ahmed K PashaVascular Division, Department of Cardiology, Mayo Clinic, Rochester, MN, 55905, USA.
Muhammad Umer SiddiquiDivision of Hospital Medicine, Capital Health Medical Center, Trenton, NJ, 08534, USA.
Muhammad Danial SiddiquiDepartment of Medicine, University of South Dakota, Vermillion, SD, 57069, USA.
Adnan AhmedAmita St. Joseph Hospital, Chicago, IL, 60657, USA.
Ammar AbdullahDepartment of Medicine, University of South Dakota, Vermillion, SD, 57069, USA.
Irbaz RiazDivision of Hematology and Oncology, Mayo Clinic, Rochester, MN, 55905, USA.
M Hassan MuradMayo Evidence-Based Practice Center, Mayo Clinic, Rochester, MN, USA.
Haraldur BjarnasonGonda Vascular Center, Mayo Clinic, Rochester, MN, 55905, USA.
Waldemar E WysokinskiVascular Division, Department of Cardiology, Mayo Clinic, Rochester, MN, 55905, USA.
Robert D McBaneVascular Division, Department of Cardiology, Mayo Clinic, Rochester, MN, 55905, USA. mcbane.robert@mayo.edu.ORCID http://orcid.org/0000-0001-8727-8029
Mayo Clinic · USUniversity of South Dakota · USMayo Clinic in Arizona · USTrinity Hospital of Augusta · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To compare the efficacy and safety of systemic and catheter directed thrombolysis for patients with pulmonary embolism. Pubmed and Cochrane Central Register of Controlled Trials were systematically searched from inception to May 31st 2020 to identify relevant studies. Outcomes of interest were in-hospital mortality and major bleeding including intracranial hemorrhage. We included 8 observational studies comprising 11,932 patients with PE. Catheter directed thrombolysis was associated with lower in-hospital mortality [RR 0.52; 95% confidence interval (CI) 0.40-0.68]. Although there was no difference in major bleeding by treatment strategy (RR 0.80; 95% CI 0.37-1.76), intracranial hemorrhage was lower in patients receiving catheter directed therapy (RR 0.66; 95% CI, 0.47-0.94).The certainty in these estimates was low. Non-randomized studies suggest that catheter directed delivery of thrombolytic therapy may be associated with lower in-hospital mortality and intracranial hemorrhage rates. These results may help inform management strategies for health care and pulmonary embolism response teams (PERT) involved in the management of high risk patients with massive or submassive pulmonary emboli.

Indexed as

Fibrinolytic AgentsPulmonary EmbolismCathetersHumansThrombolytic TherapyTreatment OutcomeFibrinolytic AgentsCatheter directed thrombolysisPulmonary embolismSystemic thrombolysis

Identifiers

PMID34463919
OpenAlexW3198637850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.