Evidence map›Paper›PMID 34463853›Full record

ArticleHandbook of experimental pharmacology2021

Controlling Wnt Signaling Specificity and Implications for Targeting WNTs Pharmacologically.

Pooja R Sonavane, Karl Willert

Abstract read
PubMed Publisher
In one paragraph

Article in Handbook of experimental pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pooja R SonavaneDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Karl WillertDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. kwillert@health.ucsd.edu.
University of California, San Diego · US

Funding

Exploring Wnt-Fzd signaling specificitiesR35GM134961 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WILLERT, KARL H · 2020 to 2024
$2.3M
NIGMS NIH HHS R35 GM134961
6 · The paper itself

Abstract

Wnt signaling is critical for proper development of the embryo and for tissue homeostasis in the adult. Activation of this signaling cascade is initiated by binding of the secreted Wnts to their receptors. With the mammalian genome encoding multiple Wnts and Wnt receptors, a longstanding question in the field has been how Wnt-receptor specificities are achieved. Emerging from these studies is a picture of exquisite control over Wnt protein production, secretion, distribution, and receptor interactions, culminating in activation of downstream signaling cascades that control a myriad of biological processes. Here we discuss mechanisms by which Wnt protein activities are tuned and illustrate how the multiple layers of regulation can be leveraged for therapeutic interventions in disease.

Indexed as

Frizzled ReceptorsWnt Signaling PathwayAdultAnimalsHumansWnt ProteinsFrizzled ReceptorsWnt ProteinsEngineered Wnt agonistExtracellular environmentFrizzled/FzdLrp5/6Ptk7Receptor–ligand interactionsRor1/2RykSignaling specificityWntWnt mimetic/surrogate

Identifiers

PMID34463853
OpenAlexW3198451018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.