ArticlePsychopharmacology2021
Early environmental enrichment and impoverishment differentially affect addiction-related behavioral traits, cocaine-taking, and dopamine D
Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Impairment of object recognition, object location and spatial working memory performance in inbred RHA vs. RLA rats.Frontiers in behavioral neuroscience · 2026Article
- Does compulsion explain addiction?Addiction biology · 2024Article
- Repeated Cocaine Intake Differentially Impacts Striatal DInternational journal of molecular sciences · 2023Article
- Motor impulsivity but not risk-related impulsive choice is associated to drug intake and drug-primed relapse.Frontiers in behavioral neuroscience · 2023Article
- Environmental enrichment alleviates cognitive and psychomotor alterations and increases adult hippocampal neurogenesis in cocaine withdrawn mice.Addiction biology · 2023Article
- Contribution of the Roman rat lines/strains to personality neuroscience: neurobehavioral modeling of internalizing/externalizing psychopathologies.Personality neuroscience · 2023Review
- Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review.Pharmacology, biochemistry, and behavior · 2022Review
- Early-Life Exposure to Non-Absorbable Broad-Spectrum Antibiotics Affects the Dopamine Mesocorticolimbic Pathway of Adult Rats in a Sex-Dependent Manner.Frontiers in pharmacology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleRisk factors for drug addiction include genetics, environment, and behavioral traits such as impulsivity and novelty preference (NP), which have been related to deficits in striatal dopamine (DA) D
objectivesWe investigated the influence of early rearing environment on striatal D
methodsAnimals were reared post-weaning in either environmental enrichment (EE) or impoverishment (EI) and were assessed at adulthood for impulsivity, NP, and propensity to cocaine SA. EE and EI rats were also scanned using single-photon emission computed tomography to concurrently measure in vivo striatal D
resultsEE vs. EI was associated with heightened impulsivity and a lack of NP in both rat lines. Higher dorsal striatal D
conclusionOur results suggest non-monotonic, environment-dependent, relationships between impulsivity, NP, and D
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.