ReviewApplied microbiology and biotechnology2021
Recent advances and new insights in biosynthesis of dendrobine and sesquiterpenes.
Review in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Research Progress on the Alkaloids ofCurrent issues in molecular biology · 2026Review
- Mining the candidate transcription factors modulating dendrobine biosynthesis under phosphate deficiency inFrontiers in plant science · 2026Article
- Parthenolide Restores Testosterone Biosynthesis After Nanoplastic Exposure by Blocking ROS-Driven NF-κB Nuclear Translocation.Antioxidants (Basel, Switzerland) · 2025Article
- Enhancement of Dendrobine Production by CRISPR/Act3.0-Mediated Transcriptional Activation of Multiple Endogenous Genes inInternational journal of molecular sciences · 2025Article
- Metabolic and transcriptional analysis of tuber expansion in Curcuma kwangsiensis.Scientific reports · 2025Article
- Development of a greenSynthetic and systems biotechnology · 2025Article
- Cinnabar-induced hormesis inFrontiers in microbiology · 2025Article
- Identifying sesterterpenoids via feature-based molecular networking and small-scale fermentation.Applied microbiology and biotechnology · 2024Article
- A Comprehensive Review of the Phytochemical Constituents and Bioactivities ofTheScientificWorldJournal · 2024Review
- Metabolic Pathway Engineering Improves Dendrobine Production inInternational journal of molecular sciences · 2023Article
- The Integration of the Metabolome and Transcriptome forMolecules (Basel, Switzerland) · 2023Article
- Exogenous and Endophytic Fungal Communities ofACS omega · 2023Article
- A Single Active-Site Mutagenesis Confers Enhanced Activity and/or Changed Product Distribution to a Pentalenene Synthase fromBioengineering (Basel, Switzerland) · 2023Article
- Chemotaxonomic Variation in Volatile Component Contents in AncientMolecules (Basel, Switzerland) · 2023Article
- Age-dependent dendrobine biosynthesis inFrontiers in microbiology · 2023Article
- Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl.AMB Express · 2022Article
- Metabolic profiling,Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sesquiterpenes are one of the most diverse groups of secondary metabolites that have mainly been observed in terpenoids. It is a natural terpene containing 15 carbon atoms in the molecule and three isoprene units with chain, ring, and other skeleton structures. Sesquiterpenes have been shown to display multiple biological activities such as anti-inflammatory, anti-feedant, anti-microbial, anti-tumor, anti-malarial, and immunomodulatory properties; therefore, their therapeutic effects are essential. In order to overcome the problem of low-yielding sesquiterpene content in natural plants, regulating their biosynthetic pathways has become the focus of many researchers. In plant and microbial systems, many genetic engineering strategies have been used to elucidate biosynthetic pathways and high-level production of sesquiterpenes. Here, we will introduce the research progress and prospects of the biosynthesis of artemisinin, costunolide, parthenolide, and dendrobine. Furthermore, we explore the biosynthesis of dendrobine by evaluating whether the biosynthetic strategies of these sesquiterpene compounds can be applied to the formation of dendrobine and its intermediate compounds. KEY POINTS: • The development of synthetic biology has promoted the study of terpenoid metabolism and provided an engineering platform for the production of high-value terpenoid products. • Some possible intermediate compounds of dendrobine were screened out and the possible pathway of dendrobine biosynthesis was speculated. • The possible methods of dendrobine biosynthesis were explored and speculated.
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