ArticleJournal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie2023
Does puberty affect oxidative stress levels and antioxidant activity of saliva in patients with fixed orthodontic appliances?
Article in Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Rapid maxillary expansion related sutural and dentoalveolar changes provoke early-term oxidative stress.BMC oral health · 2026Trial
- The Relationship Between Orthodontic Malocclusion Severity and Periodontal Clinical and Biochemical Parameters in Adolescents: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
- Salivary Total Antioxidant Capacity of Sportive Adolescents-The Effect of Antioxidant Vitamin Intake with Usual Diet and Physical Exercises.Nutrients · 2025Article
- Impact of Clear Aligners vs Conventional Brackets on Oxidant and Antioxidant Levels: A Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Oxidative stress and genotoxicity in oral epithelial cells from subjects undergoing orthodontic treatment with fixed appliances.Clinical oral investigations · 2023Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate and compare patients' oxidative stress parameters and antioxidant status with fixed orthodontic appliances during the pubertal and postpubertal growth periods.
methodsSaliva samples of 20 pubertal (mean age: 12.94 ± 0.34 years) and 20 postpubertal (mean age: 16.34 ± 0.45 years) patients were collected just before the application of fixed orthodontic appliances (T0), 4-5 h (T1), and 7 days (T2) after the initial orthodontic activation. Myeloperoxidase (MPO), nitric oxide (NO), 8‑hydroxydeoxyguanosine (8-OHdG) levels, and superoxide dismutase (SOD) activity in the saliva were examined. Repeated measures analysis of variance (ANOVA), least significant difference (LSD) pairwise comparison, and independent sample t‑tests were used to analyze the differences between the time points and growth periods, respectively.
resultsMPO levels in the saliva of patients in the pubertal period showed a significantly higher increase within the first days of treatment (T2-T1) than in patients in the postpubertal period (p < 0.05). The SOD antioxidant enzyme activity decreased in the samples from T0 to T1 in the patients in the pubertal and postpubertal groups and returned to baseline values (T0) at T2 (p < 0.01). No significant differences in the other biochemical parameters between groups were observed.
conclusionsComparing the pubertal and postpubertal groups, orthodontic force application with fixed orthodontic appliances did not change the final levels (on day 7) of antioxidant status or oxidative stress markers, except for MPO in saliva.
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