ArticleDevelopment (Cambridge, England)2021
New mouse models for high resolution and live imaging of planar cell polarity proteins in vivo.
Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Planar cell polarity-directed cell crawling drives polarized epithelial morphogenesis.Current biology : CB · 2026Article
- Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling.Development (Cambridge, England) · 2026Article
- Epithelial polarization by the planar cell polarity complex is exclusively non-cell autonomous.Science (New York, N.Y.) · 2025Article
- Radially patterned morphogenesis of murine hair follicle placodes ensures robust epithelial budding.Developmental cell · 2024Article
- Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.Development (Cambridge, England) · 2024Article
- Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation.Developmental cell · 2024Article
- A vertebrate Vangl2 translational variant required for planar cell polarity.The Journal of biological chemistry · 2024Article
- Region-specific reversal of epidermal planar polarity in the rosette fancy mouse.Development (Cambridge, England) · 2023Article
- Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development.Development (Cambridge, England) · 2022Article
- Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2.Nature communications · 2022Article
- Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity.Frontiers in cell and developmental biology · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The collective polarization of cellular structures and behaviors across a tissue plane is a near universal feature of epithelia known as planar cell polarity (PCP). This property is controlled by the core PCP pathway, which consists of highly conserved membrane-associated protein complexes that localize asymmetrically at cell junctions. Here, we introduce three new mouse models for investigating the localization and dynamics of transmembrane PCP proteins: Celsr1, Fz6 and Vangl2. Using the skin epidermis as a model, we characterize and verify the expression, localization and function of endogenously tagged Celsr1-3xGFP, Fz6-3xGFP and tdTomato-Vangl2 fusion proteins. Live imaging of Fz6-3xGFP in basal epidermal progenitors reveals that the polarity of the tissue is not fixed through time. Rather, asymmetry dynamically shifts during cell rearrangements and divisions, while global, average polarity of the tissue is preserved. We show using super-resolution STED imaging that Fz6-3xGFP and tdTomato-Vangl2 can be resolved, enabling us to observe their complex localization along junctions. We further explore PCP fusion protein localization in the trachea and neural tube, and discover new patterns of PCP expression and localization throughout the mouse embryo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.