ArticleThe Plant cell2021
Light-Response Bric-A-Brack/Tramtrack/Broad proteins mediate cryptochrome 2 degradation in response to low ambient temperature.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Cryptochrome-mediated signaling in root development.The New phytologist · 2026Review
- Light at the heart of time: How photoreceptors entrain the circadian clock.Plant communications · 2026Review
- Decoding darkness by seeking photoreceptor functions with and without light.Nature plants · 2026Review
- Molecular regulatory mechanisms ofForestry research · 2026Article
- Blue-light-enhanced interaction between ZmCRY1s and GL2 modulates epidermal wax composition in Zea mays.Nature communications · 2025Article
- The CRY1-COP1-HY5 axis mediates blue-light regulation of Arabidopsis thermotolerance.Plant communications · 2025Article
- Unraveling the signaling pathways of plant cold stress: current insights and future directions.Frontiers in plant science · 2025Review
- The lowdown on breakdown: Open questions in plant proteolysis.The Plant cell · 2024Review
- Light signaling-mediated growth plasticity in Arabidopsis grown under high-temperature conditions.Stress biology · 2022Review
- CRY2 interacts with CIS1 to regulate thermosensory flowering via FLM alternative splicing.Nature communications · 2022Article
- How plants coordinate their development in response to light and temperature signals.The Plant cell · 2022Review
- Epigenetic regulation of thermomorphogenesis inaBIOTECH · 2022Review
- Light Quality Modulates Plant Cold Response and Freezing Tolerance.Frontiers in plant science · 2022Article
- The Function and Photoregulatory Mechanisms of Cryptochromes From Moso Bamboo (Frontiers in plant science · 2022Article
- Signaling Mechanisms by Arabidopsis Cryptochromes.Frontiers in plant science · 2022Review
- A bunch of bric-à-brac (Curios) no more: on the importance of BTF proteins in mutually assured destruction in blue light.The Plant cell · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptochromes (crys) are photolyase-like blue-light receptors first discovered in Arabidopsis thaliana and later identified in all major evolutionary lineages. Crys are involved in not only blue light responses but also in temperature responses; however, whether and how cry protein stability is regulated by temperature remains unknown. Here, we show that cry2 protein abundance is modulated by ambient temperature and cry2 protein is degraded under low ambient temperature via the 26S proteasome. Consistent with this, cry2 shows high levels of ubiquitination under low ambient temperatures. Interestingly, cry2 degradation at low ambient temperatures occurs only under blue light and not under red light or dark conditions, indicating blue-light-dependent degradation of cry2 at low ambient temperature. Furthermore, low ambient temperature promotes physical interaction of Light-Response Bric-a-Brack/Tramtrack/Broad (LRB) proteins with cry2 to modulate its ubiquitination and protein stability in response to ambient temperature. LRBs promote high-temperature-induced hypocotyl elongation by modulating the protein stability of cry2 protein. These results indicate that cry2 accumulation is regulated by not only blue light but also ambient temperature, and LRBs are responsible for cry2 degradation at low ambient temperature. The stabilization of cry2 by high temperature makes cry2 a better negative regulator of temperature responses.
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