A paper, made visible

Effects of canagliflozin on major adverse cardiovascular events by baseline estimated glomerular filtration rate: Pooled Hispanic subgroup analyses from the CANVAS Program and CREDENCE trial.

Abstract evidence2 comparisonsAutomated source matching · not expert reviewed
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1

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2

Relative comparison

hazard ratio

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Reported statistic · comparison details unresolved0.83× 0.75 to 0.92×
No difference
Reported estimate95% confidence intervalEqual steps show equal ratios

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A hazard ratio compares the rate of events among those still at risk over follow-up. It is not a ratio of the percentages in a people picture. The confidence interval describes statistical uncertainty under the model, not every possible source of error.

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In the overall population, canagliflozin reduced the risk of MACE compared with placebo (HR, 0.83; 95% CI, 0.75, 0.92), with no heterogeneity observed across eGFR subgroups (interaction P = .22).

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  1. Paper abstract ↗ · Abstractabstract · Matched to source text; not expert scientific review
    In the overall population, canagliflozin reduced the risk of MACE compared with placebo (HR, 0.83; 95% CI, 0.75, 0.92), with no heterogeneity observed across eGFR subgroups (interaction P = .22).
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