Evidence map›Paper›PMID 34463363›Full record

ArticlePediatric dermatology2021

Papulo-purpuric dermatitis of childhood: a distinct PLEVA-like eruption associated to SARS-CoV-2 infection. Clinical, histopathological and immunohistochemical study of 10 cases.

Raffaele Gianotti, Lucia Restano, Mario Cutrone, Cristiana Colonna, Giovanni Fellegara, Isacco Debernardi, Francesca Boggio, Alessandro Del Gobbo, Nicola Adriano Monzani, Claudio Tripodo and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Pediatric dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Pityriasis lichenoides et varioliformis acuta after SARS-CoV-2 infection and relapse after vaccination.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Raffaele GianottiDepartment of Pathophysiology and Transplantation, Dermatology Unit, Università degli Studi di Milano, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Lucia RestanoDepartment of Clinical Sciences and Community Health, Pediatric Dermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID https://orcid.org/0000-0002-5569-8237
Mario CutroneDipartimento Materno Infantile Unità Operativa di Pediatria e Patologia Neonatale, Vicenza, Italy.
Cristiana ColonnaDepartment of Clinical Sciences and Community Health, Pediatric Dermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Giovanni FellegaraPathology Unit C.D.I. Centro Diagnostico Italiano S.p.A. Milan, Milan, Italy.
Isacco DebernardiPathology Unit C.D.I. Centro Diagnostico Italiano S.p.A. Milan, Milan, Italy.
Francesca BoggioDivision of Pathology, Università degli Studi di Milano, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Alessandro Del GobboDivision of Pathology, Università degli Studi di Milano, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Nicola Adriano MonzaniDepartment of Clinical Sciences and Community Health, Neonatal Intensive Care Unit, IRCCS Foundation Cà Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.ORCID https://orcid.org/0000-0001-7332-3888
Claudio TripodoTumor Immunology Unit. Department of Health Sciences, Istituto di Patologia Generale, University of Palermo School of Medicine, Palermo, Italy.
Carlo GelmettiDepartment of Clinical Sciences and Community Health, Pediatric Dermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Emilio BertiDepartment of Pathophysiology and Transplantation, Dermatology Unit, Università degli Studi di Milano, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
University of Milan · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITCentro Diagnostico Italiano · ITUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We observed ten children with a papular eruption with purpuric features during the SARS-CoV-2 pandemic in Northern Italy (May-December 2020). Histological examination showed signs of SARS-CoV-2-related dermatosis. Evidence of nucleocapsid viral proteins using SARS-CoV-2 (2019-nCoV) nucleocapsid antibody revealed cuticular staining of the deep portion of the eccrine glands in all cases.

Indexed as

COVID-19DermatitisPurpuraHumansPandemicsSARS-CoV-2dermatopathologypediatricPLEVASARS-CoV-2skin histopathology

Identifiers

PMID34463363
PMCPMC8646411
OpenAlexW3197376739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.