Evidence map›Paper›PMID 34463219›Full record

ArticleJournal of biomolecular structure & dynamics2022

Myxobacterial depsipeptide chondramides interrupt SARS-CoV-2 entry by targeting its broad, cell tropic spike protein.

Rey Arturo Fernandez, Mark Tristan Quimque, Kin Israel Notarte, Joe Anthony Manzano, Delfin Yñigo Pilapil, Von Novi de Leon, John Jeric San Jose, Omar Villalobos, Nisha Harur Muralidharan, M Michael Gromiha and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. New myxobacteria of theMicrobiology spectrum · 2024
    Article
  3. Article
  4. International journal of molecular sciences · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Molecules (Basel, Switzerland) · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Rey Arturo FernandezLaboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines.
Mark Tristan QuimqueLaboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines.ORCID 0000-0003-0269-5590
Kin Israel NotarteFaculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines.
Joe Anthony ManzanoLaboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines.
Delfin Yñigo PilapilLaboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines.
Von Novi de LeonLaboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines.
John Jeric San JoseLaboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines.
Omar VillalobosDepartment of Pharmacy, Faculty of Pharmacy, University of Santo Tomas, Manila, Philippines.
Nisha Harur MuralidharanDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology (IIT) Madras, Chennai, Tamil Nadu, India.
M Michael GromihaDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology (IIT) Madras, Chennai, Tamil Nadu, India.
Simone BrogiDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Allan Patrick G MacabeoLaboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines.ORCID 0000-0001-7972-106X
University of Santo Tomas · PHIndian Institute of Technology Madras · INMindanao State University – Iligan Institute of Technology · PHUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severity of the COVID-19 pandemic has necessitated the search for drugs against SARS-CoV-2. In this study, we explored

Indexed as

COVID-19DepsipeptidesEndoplasmic Reticulum Chaperone BiPHumansMolecular Dynamics SimulationPandemicsProtein BindingSARS-CoV-2Spike Glycoprotein, CoronavirusDepsipeptidesEndoplasmic Reticulum Chaperone BiPSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Antiviral agentsCOVID-19molecular dockingprotein-protein interactionsSARS-CoV-2 spike proteins and variants

Identifiers

PMID34463219
PMCPMC8436362
OpenAlexW3198085544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.