Evidence map›Paper›PMID 34463118›Full record

ArticleJournal of comparative effectiveness research2021

Comparative effectiveness research in COVID-19 using real-world data: methodological considerations.

Stephanie H Read, Artak Khachatryan, Aastha Chandak, Roman Casciano, Paul Hodgkins, Richard Haubrich, Essy Mozaffari

Abstract readEditorial
In one paragraph

Article in Journal of comparative effectiveness research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Real-world effectiveness of early remdesivir in reducing mortality among vulnerable patients hospitalized for COVID-19: Evidence for clinical pharmacists and inpatient care providers.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2026
    Article
  2. Article
  3. Article
  4. Lower Mortality Risk Associated With Remdesivir + Dexamethasone Versus Dexamethasone Alone for the Treatment of Patients Hospitalized for COVID-19.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  5. Article
  6. Management of Vulnerable Patients Hospitalized for COVID-19 With Remdesivir: A Retrospective Comparative Effectiveness Study of Mortality in US Hospitals.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  7. Article
  8. Article
  9. Remdesivir retreatment: another unproven intervention for COVID-19.The Journal of antimicrobial chemotherapy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephanie H ReadCertara, London, UK.ORCID 0000-0002-2087-7358
Artak KhachatryanCertara, London, UK.
Aastha ChandakCertara, New York, NY 10017, USA.ORCID 0000-0001-5653-435X
Roman CascianoCertara, New York, NY 10017, USA.ORCID 0000-0002-7083-9536
Paul HodgkinsGilead Sciences, Foster City, CA 94404, USA.
Richard HaubrichGilead Sciences, Foster City, CA 94404, USA.ORCID 0000-0002-9435-2386
Essy MozaffariGilead Sciences, Foster City, CA 94404, USA.

Funding

Gilead Sciences
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Comparative Effectiveness ResearchCOVID-19HumansResearch DesignSARS-CoV-2biascomparative effectiveness studiesconfoundingCOVID-19real-world data

Identifiers

PMID34463118
PMCPMC8407277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.