Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
Dinh Bui, Taijun Yin, Shengnan Duan, Bo Wei, Peiying Yang, Stuart J Wong, Ming You, Rashim Singh, Ming Hu
Article in Journal of natural products, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors at 3 institutions in 1 country.
Dinh BuiDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77004, United States.ORCID 0000-0003-2161-5664
Taijun YinDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77004, United States.
Shengnan DuanDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77004, United States.
Bo WeiDepartment of Palliative, Rehabilitation and Integrative Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
Peiying YangDepartment of Palliative, Rehabilitation and Integrative Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
Stuart J WongDepartment of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
Ming YouDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.ORCID 0000-0002-9741-268X
Rashim SinghDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77004, United States.
Ming HuDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77004, United States.
University of Houston · USMedical College of Wisconsin · USThe University of Texas MD Anderson Cancer Center · US
Funding
Disposition of Flavonoids via Metabolic InterplayR01GM070737 · NIGMS · UNIVERSITY OF HOUSTON · PI HU, MING · 2006 to 2017
$3.7M
Inhibition of Oral Tumorigenesis by Antitumor BR01CA205633 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI HU, MING, WONG, STUART J · 2017 to 2022
This study aims to characterize the pharmacokinetic (PK) profiles and identify important bioavailability barriers and pharmacological pathways of the key active components (KACs) of Antitumor B (ATB), a chemopreventive agent. KACs (matrine, dictamine, fraxinellone, and maackiain) of ATB were confirmed using the antiproliferative assay and COX-2 inhibition activities in oral cancer cells. The observed
Indexed as
Biological AvailabilityAlkaloidsAnimalsBenzofuransChemopreventionDrugs, Chinese HerbalMatrinesMiceMice, Inbred C57BLMolecular StructureMouth NeoplasmsNetwork PharmacologyPhytoalexinsPterocarpansQuinolinesQuinolizinesAlkaloidsAntitumor BBenzofuransdictamnineDrugs, Chinese HerbalfraxinelloneinerminMatrinesPhytoalexinsPterocarpansQuinolinesQuinolizines
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer. · full record | OpenQuestion