Evidence map›Paper›PMID 34462872›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2021

Effects of Nelumbo nucifera Leaf Extract on Obesity.

Enuo Liu, Hiroshi Tsuboi, Shuuji Ikegami, Tomonori Kamiyama, Yukio Asami, Luyi Ye, Munehiro Oda, Zai-Si Ji

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Lotus (Nutrients · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Enuo LiuGraduate School of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan.
Hiroshi TsuboiDivision of Research and Development, Meiji Co., Ltd, 1-29-1 Nanakuni, Hachiouji, Tokyo, 192-0919, Japan.
Shuuji IkegamiDivision of Research and Development, Meiji Co., Ltd, 1-29-1 Nanakuni, Hachiouji, Tokyo, 192-0919, Japan.
Tomonori KamiyamaDivision of Research and Development, Meiji Co., Ltd, 1-29-1 Nanakuni, Hachiouji, Tokyo, 192-0919, Japan.
Yukio AsamiDivision of Research and Development, Meiji Co., Ltd, 1-29-1 Nanakuni, Hachiouji, Tokyo, 192-0919, Japan.
Luyi YeNHC Key Laboratory of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research), Fudan University, 2140 Xietu road, Shanghai, 200032, China.
Munehiro OdaGraduate School of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan.
Zai-Si JiNHC Key Laboratory of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research), Fudan University, 2140 Xietu road, Shanghai, 200032, China. zai-si_ji@kta.biglobe.ne.jp.ORCID http://orcid.org/0000-0002-6038-1517
Meiji (Japan) · JPNihon University · JPFudan University · CNUnitika (Japan) · JP

Funding

National Natural Science Foundation of China 81803228
6 · The paper itself

Abstract

The two main components from a Nelumbo nucifera leaf extract (NnEx) were investigated for their ability to prevent triglyceride accumulation and promoting lipolysis. Sun-dried Nelumbo nucifera leaves were immersed in hot water to extract the soluble components, and the resulting solution was analyzed by LC-MS and nuclear magnetic resonance. The results showed that quercetin-3-O-ß-glucuronide (Q3GA) and quercetin were the key components of the NnEx. In vitro experiments confirmed that quercetin and Q3GA functioned in lipid metabolism by promoting triglyceride degradation through inhibition of the cAMP pathway. In vivo experiments showed that NnEx ingestion inhibited the accumulation of neutral fats in ICR mice and transitioned the hepatocytes of type II diabetic KK-Ay mice out of glycogenosis. These results highlight the ability of NnEx to control metabolism by modulating fat and sugar absorption and may provide an interesting novel treatment for obesity and related lifestyle diseases such as type II diabetes.

Indexed as

Diabetes Mellitus, Type 2NelumboAnimalsMiceMice, Inbred ICRObesityPlant ExtractsPlant LeavesPlant ExtractsAdipocyte differentiationcAMP activityFlavonoidsNelumbo nuciferaQuercetin-3-O-ß-glucuronideTriglyceride lipolysis

Identifiers

PMID34462872
OpenAlexW3197115092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.