Evidence map›Paper›PMID 34462744›Full record

ArticlebioRxiv : the preprint server for biology2021

The Lambda variant of SARS-CoV-2 has a better chance than the Delta variant to escape vaccines.

Haolin Liu, Pengcheng Wei, Qianqian Zhang, Katja Aviszus, Jared Linderberger, John Yang, Junfeng Liu, Zhongzhou Chen, Hassan Waheed, Lyndon Reynoso and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Haolin LiuDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA.
Pengcheng WeiDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA.
Qianqian ZhangState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agriculture University, Beijing 100193, People's Republic of China.
Katja AviszusDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA.
Jared LinderbergerDepartment of Biochemistry and Molecular Genetics, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216.
John YangDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Junfeng LiuState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agriculture University, Beijing 100193, People's Republic of China.
Zhongzhou ChenState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agriculture University, Beijing 100193, People's Republic of China.
Hassan WaheedDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA.
Lyndon ReynosoDepartment of Pharmacy, National Jewish Health, Denver, CO80206, USA.
Gregory P DowneyDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
Stephen K FrankelDepartment of Medicine, National Jewish Health, Denver, CO 80206, USA.
John KapplerDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA.
Philippa MarrackDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA.
Gongyi ZhangDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO 80206, USA and Department of Immunology and Microbiology, School of Medicine, Anschutz Medical Center, University of Colorado, Aurora, CO 80216, USA.

Funding

CHARACTERISTICS OF T CELL RECEPTORSR01AI018785 · NIAID · NATIONAL JEWISH HEALTH · PI MARRACK, PHILIPPA C. · 1985 to 2022
$7.3M
Histone Arginine Demethylation through CleavageR01GM135421 · NIGMS · NATIONAL JEWISH HEALTH · PI ZHANG, GONGYI · 2020 to 2023
$1.7M
NIAID NIH HHS R01 AI018785NIGMS NIH HHS R01 GM135421
6 · The paper itself

Abstract

The newly emerging variants of SARS-CoV-2 from India (Delta variant) and South America (Lambda variant) have led to a higher infection rate of either vaccinated or unvaccinated people. We found that sera from Pfizer-BioNTech vaccine remain high reactivity toward the receptor binding domain (RBD) of Delta variant while it drops dramatically toward that of Lambda variant. Interestingly, the overall titer of antibodies of Pfizer-BioNTech vaccinated individuals drops 3-fold after 6 months, which could be one of major reasons for breakthrough infections, emphasizing the importance of potential third boost shot. While a therapeutic antibody, Bamlanivimab, decreases binding affinity to Delta variant by ~20 fold, it fully lost binding to Lambda variant. Structural modeling of complexes of RBD with human receptor, Angiotensin Converting Enzyme 2 (ACE2), and Bamlanivimab suggest the potential basis of the change of binding. The data suggest possible danger and a potential surge of Lambda variant in near future.

Identifiers

PMID34462744
PMCPMC8404886

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.