Evidence map›Paper›PMID 34462656›Full record

ArticleMolecular and clinical oncology2021

p53 protein expression in synchronously occurring dedifferentiating stages of thyroid cancer in a patient with neurofibromas: A case report.

Georgios Boutzios, Eleni Papaoiconomou, Andreas Pikoulis, Konstantinos Nastos, Despoina Pouloudi, Anastasia Pikouli, Eleni Koukoulioti, Andreas Lazaris, Emmanouil Pikoulis

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Article in Molecular and clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Georgios BoutziosDepartment of Pathophysiology, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Eleni PapaoiconomouDepartment of Pathophysiology, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Andreas PikoulisThird Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Konstantinos NastosThird Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Despoina PouloudiFirst Department of Pathology Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Anastasia PikouliThird Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Eleni KoukouliotiDepartment of Pathophysiology, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Andreas LazarisFirst Department of Pathology Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Emmanouil PikoulisThird Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
National and Kapodistrian University of Athens · GRLaiko General Hospital of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) have been hypothesized to arise from well-differentiated thyroid carcinoma (WDTC) due to frequently reported synchronous and metachronous occurrence. Loss of normal p53 function has been implicated in this dedifferentiation process. The current case report presents a 60-year-old male with multiple neurofibromas who underwent total thyroidectomy due to multiple palpable thyroid nodules. Histopathological examination revealed three foci of predominantly papillary, but also follicular carcinoma growth pattern, and two lesions with histological features of insular and trabecular variant, with the larger one showing foci of anaplastic transition. Nuclear p53 protein accumulation, corresponding to mutant abnormally stabilized p53, was higher in more aggressive variants compared with WDTC. The somatic molecular events and downstream pathways of this dedifferentiation course have not been unraveled yet. The present case report demonstrated the simultaneous presence of three divergent histological subtypes in a single thyroid gland, with progressive enhancement of nuclear p53 protein expression, associated with mutant p53 protein, in the more aggressive variants. This is a rare case of progressive enhancement of mutant nuclear p53 protein expression in multifocal thyroid tumor areas consisting of WDTC, PDTC and ATC histological types, highlighting the possibility that WDTC can progress to PDTC and then ATC through an intricate procedure, involving loss of normal p53 function.

Indexed as

anaplastic carcinomafollicular carcinomap53papillary carcinomapoorly differentiated carcinoma

Identifiers

PMID34462656
PMCPMC8375044
OpenAlexW3189928277

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