Evidence map›Paper›PMID 34462546›Full record

ArticleScientific reports2021

Comparative analysis of therapeutic effects between medium cut-off and high flux dialyzers using metabolomics and proteomics: exploratory, prospective study in hemodialysis.

Hyo Jin Kim, Eun Young Seong, Wonho Lee, Suhkmann Kim, Hee-Sung Ahn, Jeonghun Yeom, Kyunggon Kim, Chae Hwa Kwon, Sang Heon Song

Open access · goldAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  3. From Mechanisms to Diseases: The Succinate-GPR91 Axis in Cardiometabolic Diseases.Journal of cardiovascular translational research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hyo Jin KimDepartment of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Eun Young SeongDepartment of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Wonho LeeDepartment of Chemistry, Center for Proteome Biophysics and Chemistry Institute for Functional Materials, Pusan National University, Busan, Korea.
Suhkmann KimDepartment of Chemistry, Center for Proteome Biophysics and Chemistry Institute for Functional Materials, Pusan National University, Busan, Korea.
Hee-Sung AhnAsan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
Jeonghun YeomConvergence Medicine Research Center, Asan Institute for Life Sciences, Seoul, Korea.
Kyunggon KimAsan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.
Chae Hwa KwonBiomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Sang Heon SongDepartment of Internal Medicine, Pusan National University Hospital, Busan, Korea. shsong0209@gmail.com.
Pusan National University Hospital · KRAsan Medical Center · KRPusan National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this single-center prospective study of 20 patients receiving maintenance hemodialysis (HD), we compared the therapeutic effects of medium cut-off (MCO) and high flux (HF) dialyzers using metabolomics and proteomics. A consecutive dialyzer membrane was used for 15-week study periods: 1st HF dialyzer, MCO dialyzer, 2nd HF dialyzer, for 5 weeks respectively.

Indexed as

Renal DialysisAdultAgedCell ProliferationChromatography, LiquidComplement System ProteinsDiscriminant AnalysisFemaleHemodiafiltrationHumansInflammationInsulin ResistanceLinear ModelsMagnetic Resonance SpectroscopyMaleMembranes, ArtificialComplement System ProteinsMembranes, Artificial

Identifiers

PMID34462546
PMCPMC8405670
OpenAlexW3198370615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.