ArticleCommunications biology2021
Campylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Triggers of Guillain-Barré Syndrome:International journal of molecular sciences · 2022Pooled it
- AcceleratingProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Oropharyngeal Microbiota Associated with Sore Throat in Acute Upper Respiratory Tract Infections.Current microbiology · 2026Article
- Seasonal dynamics, antimicrobial resistance, and genetic lineages of thermotolerantScience in One Health · 2026Article
- A review of chronic enterocolitis of rhesus macaques (Frontiers in veterinary science · 2026Review
- Article
- Growth rates and metabolic traits differ by diarrhoeal manifestation inJournal of medical microbiology · 2025Article
- Methicillin-sensitiveMicrobial genomics · 2025Article
- Transcriptomic and Metabolomic Correlates of Increased Colonic Permeability in Postinfection Irritable Bowel Syndrome.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025Article
- Potential Pathogens Associated with Colorectal Cancer.Current pharmaceutical biotechnology · 2025Review
- A One Health approach for the genomic characterization of antibiotic-resistantFrontiers in microbiology · 2025Article
- Longitudinal Changes in the Gut Microbiome of Patients With Irritable Bowel Syndrome AfterGastro hep advances · 2025Review
- Diversity ofmSphere · 2024Article
- Machine learning to attribute the source of Campylobacter infections in the United States: A retrospective analysis of national surveillance data.The Journal of infection · 2024Article
- Molecular Responses of the Eukaryotic Cell Line INT407 on the InternalizedPathogens (Basel, Switzerland) · 2024Article
- Campylobacter jejuni virulence factors: update on emerging issues and trends.Journal of biomedical science · 2024Review
- Whole-genome sequences ofMicrobiology resource announcements · 2024Article
- Evidence of potentialMicrobial genomics · 2023Article
- Campylobacter concisus from chronic inflammatory bowel diseases stimulates IL-8 production in HT-29 cells.Gut pathogens · 2023Article
- Whole-genome-based characterization ofMicrobial genomics · 2023Article
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 2 countries.
Funding
Abstract
Campylobacter enterocolitis may lead to post-infection irritable bowel syndrome (PI-IBS) and while some C. jejuni strains are more likely than others to cause human disease, genomic and virulence characteristics promoting PI-IBS development remain uncharacterized. We combined pangenome-wide association studies and phenotypic assays to compare C. jejuni isolates from patients who developed PI-IBS with those who did not. We show that variation in bacterial stress response (Cj0145_phoX), adhesion protein (Cj0628_CapA), and core biosynthetic pathway genes (biotin: Cj0308_bioD; purine: Cj0514_purQ; isoprenoid: Cj0894c_ispH) were associated with PI-IBS development. In vitro assays demonstrated greater adhesion, invasion, IL-8 and TNFα secretion on colonocytes with PI-IBS compared to PI-no-IBS strains. A risk-score for PI-IBS development was generated using 22 genomic markers, four of which were from Cj1631c, a putative heme oxidase gene linked to virulence. Our finding that specific Campylobacter genotypes confer greater in vitro virulence and increased risk of PI-IBS has potential to improve understanding of the complex host-pathogen interactions underlying this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.