ArticleScientific reports2021
Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 69 citations in OpenAlex.
- A potential association of SLC2A9 variant rs7442295 with uric acid at baseline and in interaction with iloperidone.The pharmacogenomics journal · 2026Trial
- Serum Uric Acid Levels and the Risk of Breast Cancer and Benign Breast Tumors: A Systematic Review and Meta-Analysis.Health science reports · 2026Article
- Sex-Specific Association of Drinking Habit and Alcohol Beverage Type With Serum Uric Acid in a Healthy Population.Journal of Korean medical science · 2026Article
- Genetic Association Between Sex Hormones, Serum Urate, and Gout: A Comprehensive Mendelian Randomization Study.International journal of endocrinology · 2026Article
- Baseline Risk Factors and Predictive Nomogram for Short-Term Persistent Hyperuricemia Following Laparoscopic Sleeve Gastrectomy: A Dual Center Study.Obesity surgery · 2025Article
- Nutrition-related biomarkers of metabolic disorders among immigrants in Athens, Greece: a cross- sectional study.Journal of diabetes and metabolic disorders · 2025Article
- Sex-related disparities in cognitive impairment in kidney transplant patients with kidney failure.Journal of nephrology · 2025Article
- The relationship between high serum UA levels and decidualization and angiogenesis in endometrium.Scientific reports · 2025Article
- Age and gender intersectionality among African Americans: Salivary uric acid is associated with shorter telomere length in younger adults and men.Psychoneuroendocrinology · 2025Article
- Metabolic Dysfunction-Associated Steatotic Liver Disease in Children with Obesity: Sex-Stratified Analysis of Hepatic Enzyme Profiles and Serum Uric Acid.Healthcare (Basel, Switzerland) · 2025Article
- Effectiveness of Allopurinol on Uric Acid and Pediatric Chronic Kidney Disease Severity in the Chronic Kidney Disease in Children Study.Kidney medicine · 2025Article
- Article
- Potential links between serum uric acid levels and testosterone levels in adult males: a cross-sectional study.Scientific reports · 2025Article
- Association of Serum Uric Acid Levels with Cardiometabolic Factors in Adolescents with Obesity: A Cross-Sectional Study.Metabolites · 2025Article
- Aggression and Justice Involvement: Does Uric Acid Play a Role?Brain sciences · 2025Article
- Gender Differences in Clinical and Biochemical Variables of Patients Affected by Bipolar Disorder.Brain sciences · 2025Article
- Trends and burden of gout among adolescents aged 10-24 years: insights from the global burden of disease study 2021.Frontiers in public health · 2025Article
- Comparison of different insulin resistance surrogates in predicting hyperuricemia in non-diabetic Yi residents in Yunnan Province.Frontiers in endocrinology · 2025Article
- Sex differences in the relationship between parathyroid hormone and uric acid in osteoporotic fracture patients: insights from a retrospective cross-sectional study.Frontiers in endocrinology · 2025Article
- Correlation Analysis between Serum Uric Acid Levels and Bone Mineral Density in Children with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Men have higher circulating levels of uric acid than women. This sex difference is suspected to be a result of suppressive effects of estradiol on uric acid. If so, estradiol would be inversely associated with circulating uric acid. This study aimed to test this hypothesis. This cross-sectional study included 9472 participants (weighted sample size of 184,342,210) aged 12-80 years from the 2013 to 2016 US National Health and Nutrition Examination Survey. Associations of sex hormones with uric acid were analyzed using weighted least squares regression, adjusting for demographic characteristics, lifestyle risk factors, and comorbidities. Neither free nor bioavailable estradiol was inversely associated with circulating uric acid in adolescent boys or girls, or adult men or women, or perimenopausal women after full adjustment. The sex difference in uric acid was established during adolescence as a result of a dramatic increase in uric acid in adolescent boys. During adolescence, the increase in estradiol in girls over time was accompanied by a relatively unchanged level of uric acid. All three fractions of estradiol (free, bioavailable, and total) were positively associated with uric acid in adolescent boys and girls after full adjustment. In adolescent boys, all three fractions of testosterone were positively associated with serum uric acid, and sex hormone-binding globulin was inversely associated with uric acid after full adjustment. These results suggest that estradiol is not inversely associated with circulating uric acid in adolescents and the establishment of sex difference in circulating uric acid during adolescence is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys.
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