Evidence map›Paper›PMID 34462509›Full record

ArticleScientific reports2021

Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study.

Takehiro Ota, Yoshihiro Nishida, Kunihiro Ikuta, Satoshi Tsukushi, Kenji Yamada, Eiji Kozawa, Hiroshi Urakawa, Shiro Imagama

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. TGCT of the shoulder - a case series and literature review.Archives of orthopaedic and trauma surgery · 2026
    Review
  3. Predictors of malignancy in surgically removed foot and ankle masses: a retrospective multi-center study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Takehiro OtaDepartment of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Yoshihiro NishidaDepartment of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. ynishida@med.nagoya-u.ac.jp.ORCID 0000-0002-7511-6388
Kunihiro IkutaDepartment of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Satoshi TsukushiDepartment of Orthopaedic Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.
Kenji YamadaDepartment of Orthopaedic Surgery, Okazaki City Hospital, Okazaki, Aichi, Japan.
Eiji KozawaDepartment of Orthopaedic Surgery, Nagoya Memorial Hospital, Nagoya, Aichi, Japan.
Hiroshi UrakawaDepartment of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Shiro ImagamaDepartment of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Nagoya University · JPNagoya Memorial Hospital · JPAichi Cancer Center · JPNagoya University Hospital · JPOkazaki City Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteochondral destruction and a high recurrence rate after surgery are major concerns that make difficult the treatment course of tenosynovial giant cell tumor. The aims of this study were to elucidate rates of postoperative local recurrence and osteochondral destruction, as correlated with various demographic factors. Eighty surgically treated patients with intra-articular tumors (knee: 49, ankle and foot: 12, hip: 10, others: 9) were included in this study. Factors including age, disease type (diffuse/localized), location, existence of osteochondral destruction were correlated with local recurrence or development/progression of osteochondral destruction. The 5-year local recurrence free survival rate was 71.4%. Diffuse type (n = 59, localized: n = 21) (P = 0.023) and knee location (P = 0.002) were independent risk factors for local recurrence. Diffuse type (P = 0.009) was a significant risk factor, and knee location (P = 0.001) was a negative factor for osteochondral destruction at the initial examination. Progression of osteochondral destruction was observed more often in cases with local recurrence (P = 0.040) and findings of osteochondral destruction at the initial examination (P = 0.029). Diffuse type is a factor that should be noted for both local recurrence and osteochondral destruction, while local recurrence occurs but osteochondral destruction is less observed in the knee.

Indexed as

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleGiant Cell Tumor of Tendon SheathHip JointHumansMagnetic Resonance ImagingMaleMiddle AgedNeoplasm Recurrence, LocalOsteochondritisProportional Hazards Models

Identifiers

PMID34462509
PMCPMC8405684
OpenAlexW3170815740

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.