Evidence map›Paper›PMID 34462468›Full record

ArticleScientific reports2021

Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus.

Ya-Wen Lin, Ming-Hung Lin, Lee-Wen Pai, Jen-Wei Fang, Chih-Hsin Mou, Fung-Chang Sung, Ya-Ling Tzeng

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

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  5. Association between multiple complications of pregnancy and risk of cardiovascular disease in a large cohort.International journal of cardiology. Cardiovascular risk and prevention · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Ya-Wen LinSchool of Nursing and Graduate Institute of Nursing, China Medical University, Shui-Nan Campus, 100 Jingmao Rd. Sec. 1, Taichung, 406040, Taiwan.
Ming-Hung LinDepartment of Pharmacy and Master Program, Tajen University, Pingtung, Taiwan.
Lee-Wen PaiDepartment of Nursing, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Jen-Wei FangDepartment of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan.
Chih-Hsin MouManagement Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
Fung-Chang Sung *Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
Ya-Ling Tzeng *School of Nursing and Graduate Institute of Nursing, China Medical University, Shui-Nan Campus, 100 Jingmao Rd. Sec. 1, Taichung, 406040, Taiwan. tyaling@mail.cmu.edu.tw.
China Medical University · TWAsia University · TWCentral Taiwan University of Science and Technology · TWChina Medical University Hospital · TWTajen University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate birth outcomes in women with hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM), we used insurance data of Taiwan to evaluate 11 adverse neonatal outcomes of infants born to women with HDP (N = 7775) and with both HDP and GDM (HDP/GDM) (N = 1946), comparing to women with neither disorder (N = 19,442), matched by age. The impacts of preeclampsia/eclampsia were also evaluated. Results showed that Caesarean section delivery was near 1.7-fold greater in the HDP/GDM and HDP groups than in comparisons. The preterm delivery rates were more than threefold greater in HDP/GDM group and HDP group than in comparisons with adjusted odds ratios (aORs) of 4.84 (95% confidence interval (CI) 4.34-5.40) and 3.92 (95% CI 3.65-4.21), respectively, followed by jaundice (aORs 2.95 (95% CI 2.63-3.33) and 1.90 (95% CI 1.76-2.06)), and small gestation age (SGA) (aORs 6.57 (95% CI 5.56-7.75) and 5.81 (95% CI 5.15-6.55)). Incidence rates of birth trauma, patent ductus arteriosus, atrial septal defect, respiratory distress syndrome, and neonatal hypoglycemia were also higher in the HDP/GDM and HDP groups than in the comparison group. Most adverse outcomes increased further in women with preeclampsia or eclampsia. In conclusion, women with HDP are at elevated risks of adverse neonatal outcomes. Risks of most adverse outcomes increase further for women with both HDP and GDM. Preeclampsia or eclampsia may also contribute to these outcomes to higher risk levels. Every pregnant woman with these conditions deserves specialized prenatal care.

Indexed as

Pregnancy OutcomeAdolescentAdultCase-Control StudiesCesarean SectionDatabases, FactualDiabetes, GestationalEclampsiaFemaleHumansInfant, Low Birth WeightJaundiceMiddle AgedOdds RatioPre-EclampsiaPregnancy

Identifiers

PMID34462468
PMCPMC8405617
OpenAlexW3198041838

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.