ArticleScientific reports2021
Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Transcranial alternating current stimulation over left DLPFC modulates feedback processing: a simultaneous tACS-fMRI study.Translational psychiatry · 2026Article
- Neural Correlates of Borderline Personality Disorder (BPD) Based on Electroencephalogram (EEG)-A Mechanistic Review.International journal of molecular sciences · 2025Review
- Simultaneous EEG-fMRI Reveals a Visual Working Memory Encoding Network Related to Theta Oscillatory Activity in Healthy Subjects.Human brain mapping · 2025Article
- From surface to depth: Using deep learning to predict striatal fMRI reward signaling from EEG.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
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Abstract
Previous studies using imaging techniques such as electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) have identified neurophysiological markers of impaired feedback processing in patients with Borderline Personality Disorder (BPD). These mainly include reduced oscillatory activity in the theta frequency range in the EEG and altered activations in frontal and striatal regions in fMRI studies. The aim of the present study is to integrate these results using a coupling of simultaneously recorded EEG and fMRI. Simultaneous EEG (64-channel) and fMRI (3-Tesla Siemens Prisma) was recorded whilst participants (19 BPD patients and 18 controls) performed a gambling task. Data was analysed for the two imaging techniques separately as well as in a single-trial coupling of both modalities. Evoked theta oscillatory power as a response to loss feedback was reduced in BPD patients. EEG-fMRI coupling revealed an interaction between feedback valence and group in prefrontal regions centering in the dorsolateral prefrontal cortex (dlPFC), with healthy controls showing stronger modulation by theta responses during loss when compared to gain feedback and the opposite effect in BPD patients. Our results show multiple alterations in the processing of feedback in BPD, which were partly linked to impulsivity. The dlPFC was identified as the seed of theta-associated activation differences.
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