Evidence map›Paper›PMID 34462445›Full record

ArticleNature communications2021

NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity.

Wenwen Cheng, Ermelinda Ndoka, Jessica N Maung, Warren Pan, Alan C Rupp, Christopher J Rhodes, David P Olson, Martin G Myers

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Cellular coding of ingestion in the caudal brainstem.bioRxiv : the preprint server for biology · 2026
    Article
  10. Review
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  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. The ARCNature communications · 2025
    Article
  18. Novel neural pathways targeted by GLP-1R agonists and bariatric surgery.Pflugers Archiv : European journal of physiology · 2025
    Review
  19. Article
  20. Molecular Ontology of the Nucleus of Solitary Tract.The Journal of comparative neurology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wenwen ChengDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. wenwenc@umich.edu.ORCID 0000-0002-5462-8245
Ermelinda NdokaDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Jessica N MaungDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-4289-0614
Warren PanDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Alan C RuppDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Christopher J RhodesResearch and Early Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.ORCID 0000-0002-7450-1110
David P OlsonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Martin G MyersDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. mgmyers@umich.edu.ORCID 0000-0001-9468-2046
University of Michigan · USAstraZeneca (United States) · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3M
Project 3: Neural mediators in the metabolic effects of Vertical Sleeve GastrectomyP01DK117821 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANDOVAL, DARLEEN A. · 2019 to 2023
$9.3M
Unique Roles for Defined PVH Neurons in the Control of Energy BalanceR01DK104999 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLSON, DAVID P · 2016 to 2020
$2.5M
Unique Roles for Defined PVH Neurons in the Control of Energy BalanceR56DK104999 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLSON, DAVID P · 2015 to 2015
$156k
NIDDK NIH HHS P01 DK117821NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK104999NIDDK NIH HHS R56 DK104999
6 · The paper itself

Abstract

Calcitonin receptor (Calcr)-expressing neurons of the nucleus tractus solitarius (NTS; Calcr

Indexed as

AnimalsAppetiteDietEatingEnergy MetabolismFemaleHumansHypothalamusLeptinMaleMelanocortinsMiceMice, Inbred C57BLNeuronsObesityProlactin-Releasing HormoneLeptinMelanocortinsPrlh protein, mouseProlactin-Releasing HormoneReceptors, Calcitonin

Identifiers

PMID34462445
PMCPMC8405610
OpenAlexW3196819652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.