Evidence map›Paper›PMID 34462398›Full record

ArticleMolecules and cells2021

Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking.

Julie J Hong, Kyung Eun Kim, So Young Park, Jinwoong Bok, Jeong Taeg Seo, Seok Jun Moon

Open access · diamondAbstract read
In one paragraph

Article in Molecules and cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Biallelic InactivatingInternational journal of molecular sciences · 2022
    Article
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  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Julie J HongDepartment of Oral Biology, BK 21 FOUR Project, Yonsei University College of Dentistry, Seoul 03722, Korea.ORCID https://orcid.org/0000-0002-3106-693X
Kyung Eun KimDepartment of Oral Biology, BK 21 FOUR Project, Yonsei University College of Dentistry, Seoul 03722, Korea.ORCID https://orcid.org/0000-0002-4525-1132
So Young ParkDepartment of Oral Biology, BK 21 FOUR Project, Yonsei University College of Dentistry, Seoul 03722, Korea.ORCID https://orcid.org/0000-0003-1154-7274
Jinwoong BokDepartment of Anatomy, Yonsei University College of Medicine, Seoul 03722, Korea.ORCID https://orcid.org/0000-0003-1958-1872
Jeong Taeg SeoDepartment of Oral Biology, BK 21 FOUR Project, Yonsei University College of Dentistry, Seoul 03722, Korea.ORCID https://orcid.org/0000-0003-2697-0251
Seok Jun MoonDepartment of Oral Biology, BK 21 FOUR Project, Yonsei University College of Dentistry, Seoul 03722, Korea.ORCID https://orcid.org/0000-0001-7282-2888
Yonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cilia are highly specialized organelles that extend from the cell membrane and function as cellular signaling hubs. Thus, cilia formation and the trafficking of signaling molecules into cilia are essential cellular processes. TULP3 and Tubby (TUB) are members of the tubby-like protein (TULP) family that regulate the ciliary trafficking of G-protein coupled receptors, but the functions of the remaining TULPs (i.e., TULP1 and TULP2) remain unclear. Herein, we explore whether these four structurally similar TULPs share a molecular function in ciliary protein trafficking. We found that TULP3 and TUB, but not TULP1 or TULP2, can rescue the defective cilia formation observed in

Indexed as

Multigene FamilyOrganogenesisAdaptor Proteins, Signal TransducingAnimalsCell LineCiliaHumansMembrane ProteinsMicePhosphatidylinositol 4,5-DiphosphateProtein BindingProtein DomainsProtein TransportAdaptor Proteins, Signal TransducingMembrane ProteinsPhosphatidylinositol 4,5-Diphosphateciliacilia formationciliary traffickingRPE1TULP

Identifiers

PMID34462398
PMCPMC8424140
OpenAlexW3197951317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.