Evidence map›Paper›PMID 34462359›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Chronic

Iti Saraav, Luisa Cervantes-Barragan, Philipp Olias, Yong Fu, Qiuling Wang, Leran Wang, Yi Wang, Matthias Mack, Megan T Baldridge, Thaddeus Stappenbeck and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Early life infection withGut microbes · 2025
    Article
  3. Lymphotoxin beta receptorInfection and immunity · 2025
    Article
  4. Article
  5. Beyond Latency: ChronicBiomedicines · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Toxoplasma-induced behavior changes - is microbial dysbiosis the missing link?Frontiers in cellular and infection microbiology · 2024
    Review
  12. Review
  13. Dendritic Cells andMicroorganisms · 2023
    Review
  14. Article
  15. ExploringFrontiers in cellular and infection microbiology · 2023
    Review
  16. From the immune system to mood disorders especially induced byFrontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Iti SaraavDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Luisa Cervantes-BarraganDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Philipp OliasDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Yong FuDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Qiuling WangDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Leran WangDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.
Yi WangDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Matthias MackDepartment of Nephrology, University of Regensburg, 93042 Regensburg, Germany.
Megan T BaldridgeDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-7030-6131
Thaddeus StappenbeckDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-5222-4987
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110; sibley@wustl.edu.
Washington University in St. Louis · USUniversity of Regensburg · DE

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
Molecular Basis of Human ToxoplasmosisR01AI118426 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2015 to 2024
$6.0M
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI118426NIDDK NIH HHS P30 DK052574
6 · The paper itself

Abstract

Oral infection with

Indexed as

AnimalsChronic DiseaseColitisDisease SusceptibilityGastrointestinal MicrobiomeIntestinal MucosaMiceMice, Inbred C57BLMonocytesRegenerationStem CellsToxoplasmosisdisbiosisinflammationmonocytesnitric oxidetoxoplasmosis

Identifiers

PMID34462359
PMCPMC8433586
OpenAlexW3196828151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.