ArticleProceedings of the National Academy of Sciences of the United States of America2021
Ventral pallidum regulates the default mode network, controlling transitions between internally and externally guided behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Spectral dynamic causal modeling of effective connectivity across multiple brain networks in pilot trainees.iScience · 2026Article
- The structural grammar of integration and competition in the human connectome.Frontiers in computational neuroscience · 2026Article
- Ventral pallidum efferent pathways via mediodorsal thalamus and lateral habenula mediate default mode network regulation.iScience · 2025Article
- GABAergic neurons in basal forebrain exert frequency-specific modulation on auditory cortex and enhance attentional selection of auditory stimuli.Communications biology · 2025Article
- Mediodorsal thalamus and ventral pallidum contribute to subcortical regulation of the default mode network.Communications biology · 2024Article
- Temporal changes in brain morphology related to inflammation and schizophrenia: an omnigenic Mendelian randomization study.Psychological medicine · 2024Article
- A new causal centrality measure reveals the prominent role of subcortical structures in the causal architecture of the extended default mode network.Brain structure & function · 2023Article
- Dynamic subcortical modulators of human default mode network function.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Subcortical control of the default mode network: Role of the basal forebrain and implications for neuropsychiatric disorders.Brain research bulletin · 2022Review
- Ventral pallidum regulates the default mode network, controlling transitions between internally and externally guided behavior.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Abstract
Daily life requires transitions between performance of well-practiced, automatized behaviors reliant upon internalized representations and behaviors requiring external focus. Such transitions involve differential activation of the default mode network (DMN), a group of brain areas associated with inward focus. We asked how optogenetic modulation of the ventral pallidum (VP), a subcortical DMN node, impacts task switching between internally to externally guided lever-pressing behavior in the rat. Excitation of the VP dramatically compromised acquisition of an auditory discrimination task, trapping animals in a DMN state of automatized internally focused behavior and impairing their ability to direct attention to external sensory stimuli. VP inhibition, on the other hand, facilitated task acquisition, expediting escape from the DMN brain state, thereby allowing rats to incorporate the contingency changes associated with the auditory stimuli. We suggest that VP, instant by instant, regulates the DMN and plays a deterministic role in transitions between internally and externally guided behaviors.
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