Evidence map›Paper›PMID 34462310›Full record

ArticleeNeuro

Single Dose of Amphetamine Induces Delayed Subregional Attenuation of Cholinergic Interneuron Activity in the Striatum.

Samira Ztaou, Soo Jung Oh, Sophia Tepler, Sixtine Fleury, Miriam Matamales, Jesus Bertran-Gonzalez, Nao Chuhma, Stephen Rayport

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Samira ZtaouDepartment of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032 samira.ztaou@nyspi.columbia.edu stephen.rayport@nyspi.columbia.edu.ORCID 0000-0003-2058-4915
Soo Jung OhDepartment of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032.ORCID 0000-0003-4505-2333
Sophia TeplerDepartment of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032.
Sixtine FleuryDepartment of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032.
Miriam MatamalesDecision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia.
Jesus Bertran-GonzalezDecision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW 2052, Australia.
Nao ChuhmaDepartment of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032.
Stephen RayportDepartment of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032 samira.ztaou@nyspi.columbia.edu stephen.rayport@nyspi.columbia.edu.ORCID 0000-0001-9755-7486
New York Psychoanalytic Society and Institute · USUNSW Sydney · AU

Funding

Functional connectome analysis of amphetamine action at dopamine neuron synapsesR01DA038966 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI RAYPORT, STEPHEN · 2015 to 2019
$2.9M
Targeting cotransmission for circuit-specific pharmacotherapyR01MH117128 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI RAYPORT, STEPHEN · 2018 to 2022
$2.9M
Therapeutic potential of GLS1 inhibition for the pharmacotherapy of schizophreniaR01MH087758 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RAYPORT, STEPHEN · 2010 to 2014
$1.8M
NIDA NIH HHS R01 DA038966NIMH NIH HHS R01 MH087758NIMH NIH HHS R01 MH117128
6 · The paper itself

Abstract

Psychostimulants such as amphetamine (AMPH) target dopamine (DA) neuron synapses to engender drug-induced plasticity. While DA neurons modulate the activity of striatal (Str) cholinergic interneurons (ChIs) with regional heterogeneity, how AMPH affects ChI activity has not been elucidated. Here, we applied quantitative fluorescence imaging approaches to map the dose-dependent effects of a single dose of AMPH on ChI activity at 2.5 and 24 h after injection across the mouse Str using the activity-dependent marker phosphorylated ribosomal protein S6 (p-rpS6

Indexed as

AmphetamineDopamineAnimalsCholinergic AgentsInterneuronsMiceNucleus AccumbensAmphetamineCholinergic AgentsDopamineacetylcholinedopaminefluorescence imagingphosphorylated ribosomal protein S6psychostimulant

Identifiers

PMID34462310
PMCPMC8454923
OpenAlexW3197659150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.