Evidence map›Paper›PMID 34462308›Full record

ArticleeNeuro

Effects of Cooling Temperatures via Thermal K2P Channels on Regeneration of High-Frequency Action Potentials at Nodes of Ranvier of Rat Aβ-Afferent Nerves.

Hirosato Kanda, Sotatsu Tonomura, Jianguo G Gu

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Role of Voltage-Gated KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Hirosato KandaDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0003-2547-9073
Sotatsu TonomuraDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.
Jianguo G GuDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 jianguogu@uabmc.edu.
University of Alabama at Birmingham · USHyogo University of Health Sciences · JP

Funding

Mechanisms of Nociception in the Trigeminal SystemR01DE018661 · NIDCR · UNIVERSITY OF FLORIDA · PI JIANGUO GU · 2008 to 2026
$6.9M
Cellular and Ion Channel Mechanisms Underlying the Sense of Light Touch in MammalsR01DE023090 · NIDCR · UNIVERSITY OF CINCINNATI · PI JIANGUO GU · 2013 to 2026
$6.1M
Ion channels and their functions at the node of Ranvier of mammalian somatosensory afferent fibersR01NS109059 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GU, JIANGUO · 2019 to 2023
$2.2M
NIDCR NIH HHS R01 DE018661NIDCR NIH HHS R01 DE023090NINDS NIH HHS R01 NS109059
6 · The paper itself

Abstract

Temperature-sensitive two-pore domain potassium channels (thermal K2P) are recently shown to cluster at nodes of Ranvier (NRs) and play a key role in action potential (AP) regeneration and conduction on Aβ-afferent nerves. Cooling temperatures affect AP regeneration and conduction on Aβ-afferent nerves but the underlying mechanisms are not completely understood. Here, we have performed patch-clamp recordings directly at the NR in an

Indexed as

Potassium ChannelsRanvier's NodesAction PotentialsAnimalsMembrane PotentialsRatsTemperaturePotassium Channelsaction potentialAβ-afferent nervescooling temperaturenode of Ranviersaltatory conductiontwo-pore domain K+ channels

Identifiers

PMID34462308
PMCPMC8445039
OpenAlexW3198611664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.