Evidence map›Paper›PMID 34462307›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

The Role of Galanin in Cerebellar Granule Cell Migration in the Early Postnatal Mouse during Normal Development and after Injury.

Yutaro Komuro, Ludovic Galas, Yury M Morozov, Jennifer K Fahrion, Emilie Raoult, Alexis Lebon, Amanda K Tilot, Shin Kikuchi, Nobuhiko Ohno, David Vaudry and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Biochemical and Physiological Effects of Galanin in Health and Disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. Effect ofIBRO neuroscience reports · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Yutaro KomuroDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Ludovic GalasRegional Platform for Cell Imaging of Normandy, INSERM, Université de Rouen Normandie, 76000 Rouen, France.
Yury M MorozovDepartment of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510.ORCID 0000-0002-3679-6819
Jennifer K FahrionDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Emilie RaoultRegional Platform for Cell Imaging of Normandy, INSERM, Université de Rouen Normandie, 76000 Rouen, France.
Alexis LebonRegional Platform for Cell Imaging of Normandy, INSERM, Université de Rouen Normandie, 76000 Rouen, France.
Amanda K TilotDepartment of Genomic Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Shin KikuchiDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Nobuhiko OhnoDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
David VaudryRegional Platform for Cell Imaging of Normandy, INSERM, Université de Rouen Normandie, 76000 Rouen, France.
Pasko RakicDepartment of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510.
Hitoshi KomuroDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195 komuroh@ccf.org.
Cleveland Clinic Lerner College of Medicine · USInserm · FRYale University · USJichi Medical University · JP

Funding

Origin of Cortical Species-specific Distinctions.R01DA023999 · NIDA · YALE UNIVERSITY · PI RAKIC, PASKO · 2008 to 2019
$7.9M
Origin of Cortical Species-specific DistinctionsR37DA023999 · NIDA · YALE UNIVERSITY · PI PASKO RAKIC · 2020 to 2026
$5.6M
NIDA NIH HHS R01 DA023999NIDA NIH HHS R37 DA023999
6 · The paper itself

Abstract

Galanin, one of the most inducible neuropeptides, is widely present in developing brains, and its expression is altered by pathologic events (e.g., epilepsy, ischemia, and axotomy). The roles of galanin in brain development under both normal and pathologic conditions have been hypothesized, but the question of how galanin is involved in fetal and early postnatal brain development remains largely unanswered. In this study, using granule cell migration in the cerebellum of early postnatal mice (both sexes) as a model system, we examined the role of galanin in neuronal cell migration during normal development and after brain injury. Here we show that, during normal development, endogenous galanin participates in accelerating granule cell migration via altering the Ca

Indexed as

AnimalsAnimals, NewbornBrainBrain InjuriesCell MovementCells, CulturedCerebellumDose-Response Relationship, DrugFemaleGalaninMaleMiceGalaningalanin protein, mousecerebellumgalaningranule celllive cell imagingmiceneuronal migration

Identifiers

PMID34462307
PMCPMC8528496
OpenAlexW3196723085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.